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SELECTBIO Conferences Biofluid Biopsies

Sehyun Shin's Biography



Sehyun Shin, Professor & Director, Nano-Biofluignostic Engineering Research Center, Korea University and Anam/Guro Hospital of Korea University

Professor Shin is currently professor of School of Mechanical Engineering and College of Medicine at Korea University and the director of Nano-Biofluignostic Engineering Research Center. He also has served as the Editor of the Journal of Mechanical Science and Technology (JMST). His research interests include the liquid biopsy for cancer and infectious viruses and the development of microfluidic technologies for disease detection, diagnosis and therapy. He has authored more than 150 peer-reviewed papers and delivered more than 130 invited talks and plenary lectures. He is as the president of International Society of Clinical Hemorheology as well as president of Biomedical Engineering Society of Cardiovascular Diseases. Prof. Shin co-founded three startups which are commercializing technologies developed in his lab. He has garnered many research awards and honors including Presidential citation of Science and Technology Merit by the Korean government, award for the Scientist of the month by NRF, the Academic award of KSME, the Nam-Heon Academic Award for Thermal engineering, Fellow of the ISCH, Fellow of KSME and Fellow of KSOR. Finally, Prof. Shin currently heads a group of 15 researchers.

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Detection of Circulating Tumor DNA by Surface Plasmon Resonance

Tuesday, 17 November 2015 at 08:30

Add to Calendar ▼2015-11-17 08:30:002015-11-17 09:30:00Europe/LondonDetection of Circulating Tumor DNA by Surface Plasmon ResonanceSELECTBIOenquiries@selectbiosciences.com

Circulating tumor DNA (ctDNA) has been demonstrated as the most promising biomarker for non-invasive assessment of cancer as well as the most accurate predictor of cancer treatment responses. However, detection of ctDNA in blood has been faced with conventional technical limits and called for innovative technologies and methods. Here, we present a stable and selective assay for detecting of epidermal growth factor receptor (EGFR) mutation in plasma (or liquid biopsy) using DNA-DNA hybridization and Au nanoparticle probe with a lab-made surface plasmon resonance (SPR) sensometry. We prepared wild type EGFR, mutant EGFR including point mutation and deletion and control (non-complimentary). Linker DNAs coated on a sensor surface of SPR capture different quantities of three different DNA types. Due to characteristics of SPR, the whole process was monitored in real-time and completed within an hour. This study as a proof of concept can be further expanded into multiplexing detection of major and known ctDNAs, which could provide a solution for clinical unmet needs in cancer treatment and early detection.


Add to Calendar ▼2015-11-16 00:00:002015-11-17 00:00:00Europe/LondonBiofluid BiopsiesSELECTBIOenquiries@selectbiosciences.com