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SELECTBIO Conferences Next Generation Sequencing: Research to Clinic

Melanie Lehman's Biography

Melanie Lehman, Research Scientist, Queensland University of Technology

Dr Lehman is a Research Fellow (Computational Biology) at the Australian Prostate Cancer Research Centre-Queensland (APCRC-Q) and a Member of the Institute of Health and Biomedical Innovation at Queensland University of Technology in Brisbane, Australia. Dr Lehman completed her BSc in cell biotechnology at the University of Alberta in 1998 (Edmonton, Canada). She has university level training in software engineering, math and statistics, and six years of work experience in bioinformatics prior to starting her PhD. In 2011, she completed her PhD focused on prostate cancer and computational biology at the University of British Columbia (Vancouver Prostate Centre, Vancouver, Canada). Dr Lehman joined the APCRC-Q in 2012 and is currently co-leader of the Transcriptomics Section of a Movember Revolutionary Team Award (led by Prof Colleen Nelson), a joint collaboration between prostate cancer researchers in Australia, Canada and Ireland. Her research is focused on the complexity of condition-specific transcription including alternative protein-coding isoforms and non-coding RNA. She utilizes computational approaches to analyze and integrate profiling data (RNAseq, smallRNAseq and microarray) from in vitro cell culture, xenograft and patient models to study treatment resistance in advanced prostate cancer.

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RNAseq and Transcriptional Variation in Prostate Cancer

Monday, 24 February 2014 at 10:30

Add to Calendar ▼2014-02-24 10:30:002014-02-24 11:30:00Europe/LondonRNAseq and Transcriptional Variation in Prostate CancerNext Generation Sequencing: Research to Clinic in San Diego, California, USASan Diego, California,

RNAseq is revolutionizing our understanding of RNA expression and is forcing a re-evaluation of our approach to systems biology.  We have used de novo transcriptome assembly methods to identify alternative protein-coding RNAs that are missing canonical functional domains as well as regulatory long coding RNAs (lncRNAs) that are overlapping—and often mistaken for—protein-coding RNAs.  I will discuss the implications of this transcriptional variation to pathway and functional analysis in the context of our research in late stage prostate cancer.

Add to Calendar ▼2014-02-24 00:00:002014-02-25 00:00:00Europe/LondonNext Generation Sequencing: Research to ClinicNext Generation Sequencing: Research to Clinic in San Diego, California, USASan Diego, California,