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SELECTBIO Conferences Epigenetics in Drug Discovery

Tim Humphrey's Biography

Tim Humphrey, Associate Professor, University Of Oxford

Tim Humphrey is a senior group leader at the MRC-CRUK Oxford Institute for Radiation Oncology. Tim performed his doctoral studies at the University of Oxford and was an EMBO and HFSP post-doctoral research fellow at Harvard Medical School before returning to the UK to become a group leader at the MRC Genome Stability Unit, Oxfordshire. He was awarded tenure in 2003, and in 2008 he moved to the Gray Institute in Oxford and heads the Chromosome Integrity Group. As Director of Studies, he oversaw the development of the Institute’s graduate studies research programme.

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Targeting Histone H3K36me3-deficient Cancers

Wednesday, 27 January 2016 at 15:30

Add to Calendar ▼2016-01-27 15:30:002016-01-27 16:30:00Europe/LondonTargeting Histone H3K36me3-deficient CancersEpigenetics in Drug Discovery in Cambridge, UKCambridge,

Loss of the histone H3K36me3 mark is frequently observed in cancer cells, suggesting this epigenetic mark as an important therapeutic target. Evidence will be presented indicating that H3K36me3-deficient cancer cells can be effectively targeted using the WEE1 inhibitor AZD1775. The underlying mechanism of this synthetic lethality and its implications will be discussed.

Add to Calendar ▼2016-01-26 00:00:002016-01-27 00:00:00Europe/LondonEpigenetics in Drug DiscoveryEpigenetics in Drug Discovery in Cambridge, UKCambridge,