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SELECTBIO Conferences Organ-on-a-Chip Conference

Rahul S Tare's Biography

Rahul S Tare, Lecturer, University Of Southampton

Rahul was awarded a PhD from the University of Southampton (2002) and undertook postdoctoral research in the University of Massachusetts Medical School (2002-2004) and University of Southampton (2004-2010), where he was awarded the Career Track Fellowship supported by the Wellcome Trust Value in People Award (2008) and appointed to a Lectureship in Musculoskeletal Science and Bioengineering in the Faculties of Medicine and Engineering (2010). Research in Rahul’s group focuses on stem cells, tissue engineering and skeletal development. The work has been instrumental in developing strategies for isolation of skeletal stem cells (SSCs), elucidating the SSC phenotype and defining conditions to manipulate SSC differentiation into principal stromal lineages. A multidisciplinary approach encompassing skeletal cells, acoustofluidics and mathematical modelling has been harnessed to bioengineer robust cartilage grafts, and is now being extended to human embryonic stem cell-derived mesenchymal stem cells. The group also seek to understand the molecular basis of skeletal development and disease through improved appreciation of the role of molecular chaperones and co-chaperones in chondrogenesis and osteogenesis. Rahul is a recipient of the Career Establishment Award from the European Calcified Tissue Society (2011) and further details on Rahul’s publications can be found on,

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Application of Custom-built Acousto-fluidic Perfusion Bioreactor for Cartilage Tissue Engineering

Thursday, 9 July 2015 at 14:30

Add to Calendar ▼2015-07-09 14:30:002015-07-09 15:30:00Europe/LondonApplication of Custom-built Acousto-fluidic Perfusion Bioreactor for Cartilage Tissue

We have recently reported on the application of a novel acousto-fluidic perfusion bioreactor for the generation of viable, three-dimensional, scaffold-free, hyaline cartilage-like constructs of human articular chondrocytes (Lab Chip 2014; 14:4475-85). This system harnesses ultrasonic standing wave fields to promote rapid aggregation of a single cell suspension into 3D aggregates, which are levitated by the ultrasound in the lumen of the bioreactor in what is effectively a zero gravity environment, and cultured for up to 21 days in chondro-inductive medium, which is perfused continuously through the system to promote cartilage formation. The development of the acousto-fluidic perfusion bioreactor technology and its successful application for ex vivo generation of cartilage grafts, which have the potential for subsequent use in the clinic for the repair of partial thickness cartilage defects, will be elucidated in the presentation.

Add to Calendar ▼2015-07-08 00:00:002015-07-09 00:00:00Europe/LondonOrgan-on-a-Chip