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SELECTBIO Conferences Circulating DNA, Circulating RNA, Circulating Tumor Cells

Z Fan's Biography

Z Fan, Professor, University of Florida

Dr. Z. Hugh Fan is a UF Research Foundation professor in the Departments of Mechanical and Aerospace Engineering, Biomedical Engineering, and Chemistry at the University of Florida (UF). Prior to this position, he was a Principal Scientist at ACLARA BioSciences Inc. and a Member of the Technical Staff at Sarnoff Corp. Dr. Fan is a recipient of Fraunhofer-Bessel Award from Alexander von Humboldt Foundation (Germany), E.T.S. Walton Award from Science Foundation Ireland, and Career Award from National Institute of Health (US).

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Combining Aptamers with Antibodies for Isolation of Tumor Cells in Microfluidic Devices

Tuesday, 24 March 2015 at 11:00

Add to Calendar ▼2015-03-24 11:00:002015-03-24 12:00:00Europe/LondonCombining Aptamers with Antibodies for Isolation of Tumor Cells in Microfluidic

Circulating tumor cells (CTCs) in the peripheral blood are potential biomarkers for cancer diagnosis and prognosis. However, CTC are extremely rare, making their detection very challenging. To address this, we have combined aptamers with antibodies to create multivalent-binding surfaces for the capture and isolation of cancer cells.  Higher cell capture efficiency was obtained than that using either antibodies or aptamers alone.  In addition, we have employed microfluidic devices for detecting CTCs from peripheral blood samples of metastatic pancreatic cancer patients. We found that the CTC numbers correlated with the clinical outcome.

Add to Calendar ▼2015-03-23 00:00:002015-03-24 00:00:00Europe/LondonCirculating DNA, Circulating RNA, Circulating Tumor