| Conferences \ Circulating Biomarkers World Congress 2015 \ Circulating DNA, Circulating RNA, Circulating Tumor Cells \ Agenda \ Z Fan |
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Combining Aptamers with Antibodies for Isolation of Tumor Cells in Microfluidic DevicesTuesday, 24 March 2015 at 11:00  Add to Calendar ▼2015-03-24 11:00:002015-03-24 12:00:00Europe/LondonCombining Aptamers with Antibodies for Isolation of Tumor Cells in Microfluidic DevicesSELECTBIOenquiries@selectbiosciences.comCirculating tumor cells (CTCs) in the peripheral blood are potential biomarkers for cancer diagnosis and prognosis. However, CTC are extremely rare, making their detection very challenging. To address this, we have combined aptamers with antibodies to create multivalent-binding surfaces for the capture and isolation of cancer cells. Higher cell capture efficiency was obtained than that using either antibodies or aptamers alone. In addition, we have employed microfluidic devices for detecting CTCs from peripheral blood samples of metastatic pancreatic cancer patients. We found that the CTC numbers correlated with the clinical outcome. |
Add to Calendar ▼2015-03-23 00:00:002015-03-24 00:00:00Europe/LondonCirculating DNA, Circulating RNA, Circulating Tumor CellsSELECTBIOenquiries@selectbiosciences.com
