Enzyme & Binding Assays in Drug Discovery

31 May 2012, at 08:30-17:00 in Hamburg, Germany

What will I gain by attending?

• Master the basic concepts underlying enzyme and binding assays
• Learn how applications in drug discovery sometimes dictate assay optimization and interpretation which differ from textbook recommendations
• Learn how best to extract the information you need from your assays

Course Topics:

• Enzyme kinetics
• Enzyme inhibition: Competitive, noncompetitive, uncompetitive, irreversible, and promiscuous
• Multiple-substrate enzymes
• Binding equilibria and kinetics
• Deviations from classical textbook behaviour
• Optimizing enzyme and binding assays for primary vs. secondary screening
• Understanding mechanisms and extracting information from your data
• Case studies, including receptor binding, kinases, and proteases