Affordable and Effortless Low Volume Reagent Dispensing
Wednesday, 30 May 2012 at 12:15
Increased throughput and savings in reagent cost through assay miniaturization are drivers of modern pharmaceutical and biotechnology laboratories today. The Thermo Scientific Multidrop Combi nL is a reagent dispenser designed for fast and accurate dispensing of low volumes up to 1536-well plates, helping in achieving these goals. It can be used for dispensing various solutions, such as DMSO, buffers, PCR reaction mix, sequencing reagents, and even cells. Multidrop Combi nL offers flexible features at an affordable price. Due to individually controlled valves, it can dispense into any well with any volume, allowing dispensing of samples into selected wells. As a small sized instrument it easily fits into automation platforms for increased throughput. Small dead volume and accurate low volumes down to 50 nl, combined with extreme ease of use, offer reagent savings and cost effectiveness. The Multidrop Combi nL reagent dispenser is an efficient tool for pharmaceutical and biotechnology laboratories for reproducible and reliable assay results.
Managing a Collection of Stereochemically Diverse Libraries
Wednesday, 30 May 2012 at 09:30
Next-generation DNA Sequencing Techniques and Applications
Thursday, 31 May 2012 at 11:45
Next generation DNA sequencing techniques are opening fascinating opportunities in life sciences. Commercially available DNA sequencing platforms, Single molecule Real-time methods, Nanopores (also Graphene), as well as other techniques under development are described and applications in bio-medical fields discussed.Next generation DNA sequencing techniques are opening fascinating opportunities in life sciences. Commercially available DNA sequencing platforms, Single molecule Real-time methods, Nanopores (also Graphene), as well as other techniques under development are described and applications in bio-medical fields discussed.
New Approaches to Solving Old Problems in High Content Imaging of Cells in vitro
Thursday, 31 May 2012 at 09:30
To address many of the issues surrounding the use of cell based assay systems in High Content Imaging, we have developed a novel Micro-Plate Bioreactor Array and 3D assay technologies. In this presentation we will examine the tangible benefits of these technologies and how these new assay tools may be routinely incorporated into automated HCS/A workflows.
High Content Cell Based Assays in Drug Discovery: Changing the HTS Paradigm
Wednesday, 30 May 2012 at 09:00
HCS has evolved over the course of nearly two decades, enabling us to perform highly complex cellular based HCA screens; with it came data explosion requiring special logistics. I will present examples and discuss resolutions to HCS data acquisition and management.
Can Informatics Enhance API Route Design Procedures?
Wednesday, 30 May 2012 at 11:45
The presentation will describe work around a pilot study to explore the use of Isentris Reaction Planner as a tool for synthetic route design of pharmaceutical APIs.
New Possibilities of Process Modelling Languages for Workflow Automation in Laboratories
Wednesday, 30 May 2012 at 10:00
Is the new standard Business Process Model and Notation (BPMN) ready to use? How to apply Business Process Management Systems (BPMS) for heterogeneous systems integration? Is BPMN 2.0 a key for more efficiency and better quality assurance?
Utilizing Nanoliter Dispensing as a Solution for Rapid Mechanistic Profiling of Enzyme Inhibitors
Wednesday, 30 May 2012 at 14:45
A common bottle neck incurred when profiling inhibitors is the laborious pipetting stages that are normally associated in carrying out such experiments. This presentation describes how the utilization of nanolitre dispensing has provided a solution in speeding up the process of profiling these inhibitors.
Optimising Efficiency in a High-throughput Service Lab – Automation Solutions
Wednesday, 30 May 2012 at 12:15
Running a high-throughput genotyping and nucleic acid preparation service laboratory provides our instrumentation development team with a unique insight to the challenges faced by our customers in their own operations. The development of the LGC Genomics/KBioscience range of laboratory instrumentation has always been driven by innovations required to improve efficiency in our own laboratories and the presentation at this year’s ELA focuses on some of the key developments we have initiated in the areas of high-throughput MTP replication, DNA extraction, assay dispensing and liquid handling and high throughput water bath thermal cycling for PCR. The presentation includes videos, animations and graphical representations of our laboratory automation solutions, their development and overviews of the workflow solutions we have developed to optimise throughput in singleplex genotyping projects and the flexibility offered through this approach to data set generation.
High Concentration Biochemical Fragment Screening on GPCRs
Wednesday, 30 May 2012 at 16:30
The utility of high concentration biochemical fragment screening on membrane-bound drug targets less prone to biophysical detection will be presented.
NGS Sample Preparation at EMBL GeneCore
Thursday, 31 May 2012 at 12:15
Overview about laboratory workflows and automation strategies in a NGS core facility focussing on liquid handling devices.
Biobanking Applications for Genomics
Wednesday, 30 May 2012 at 17:00
Targeted Resequencing Applications in a High-throughput Laboratory
Thursday, 31 May 2012 at 09:30
High-Throughput Screening for Identification of BMP Signalling Agonists
Wednesday, 30 May 2012 at 17:30
Cell based luminescent assay has been developed for HTS identification of small molecule BMP-signaling activators, based on induction of Id-1 expression. Hit identification and follow-up strategy will be discussed.
Registration
Wednesday, 30 May 2012 at 08:00
Close of Conference
Thursday, 31 May 2012 at 15:45
Electric News for the Future of Plate Sealing
Wednesday, 30 May 2012 at 12:15
Technology Spotlight - Invenios
Wednesday, 30 May 2012 at 12:15
Compound Management Requirements to Support High Throughput Approaches to in vitro Assay Validation
Thursday, 31 May 2012 at 14:45
The Institute for Health and Consumer Protection (IHCP) hosts the European Union Reference Laboratory for Alternative Methods to Animal Testing (EURL-ECVAM) which is active in evaluating and validating in vitro cell based assays that can be used in regulatory safety assessment of chemicals. High throughput screening approaches are being investigated to expedite the process. Effective management of reference compounds including characterisation of solubility, stability, fate and traceability, is critical to ensure quality and reliability of validation results.
Management and Automation System for Complete qPCR Diagnostics Workflow
Wednesday, 30 May 2012 at 14:45
Complexity of qPCR (Real-Time Polymerase Chain Reaction) as one of the leading methods in the molecular diagnostics field, defines a clear demand for the simple qPCR workflow automation system that can ease the pressure on high level scientists.
Using Hudson's New "Guided Operation"(GO) Wizards to Improve Automation Performance for Small Work Cells
Thursday, 31 May 2012 at 12:15
The GO wizards are a new feature in SoftLinx, Hudson's powerful scheduling software. The wizard is created to take a user step by step through a complex protocol involving set up and running of liquid handling steps as well as all benchtop instruments required for the protocol including those requiring a "sneaker net" interface.
Miniaturization in Biobanking
Thursday, 31 May 2012 at 12:15
As assay technologies advance, aliquot size required for analysis is decreasing. Typical
proteomic MS biomarker assays require sample volumes of less than 50µl while biobanks
typically store much larger volumes. Sample miniaturization presents opportunities to increase aliquot numbers (and allow for greater sample utilization without the need for additional freeze/thaw cycles) while presenting opportunities to maximize storage capacity and minimize the costs of long term cryostorage of biospecimens by reducing the overall size of biobank collections. This presentation will address comparisons between smaller and larger storage volumes, tube and sealing technologies, calculations for store sizes and total energy consumption and related topics.
Next-generation DNA Sequencing Techniques and Applications
Thursday, 31 May 2012 at 11:45
Next generation DNA sequencing techniques are opening fascinating opportunities in life sciences. Commercially available DNA sequencing platforms, Single molecule Real-time methods, Nanopores (also Graphene), as well as other techniques under development are described and applications in bio-medical fields discussed.
A Global Automation Strategy in Drug Metabolism & Pharmacokinetics for PK and PK/PD Sample Preparation
Thursday, 31 May 2012 at 15:45
Significant improvement in throughput/capacity and at the same time free up time resources for the bioanalyst in discovery bioanalysis with LC-MS/MS has been accomplished by automating many individual bioanalytical tasks such as method development, sample preparation and sample analysis.
Wednesday, 30 May 2012 at 07:00
Wednesday, 30 May 2012 at 07:00
Management and Automation System for Complete qPCR Diagnostics Workflow
Wednesday, 30 May 2012 at 14:45
Complexity of qPCR (Real-Time Polymerase Chain Reaction) as one of the leading methods in the molecular diagnostics field, defines a clear demand for the simple qPCR workflow automation system that can ease the pressure on high level scientists.
Traceable Automated UV/Vis Quantification of Microliter DNA Samples
Wednesday, 30 May 2012 at 16:30
For high throughput UV/vis spectrophometric droplet characterization, use of a predefined sample definition table for sample tracking is compared to post measurement merging of sample definition and results.
Leveraging Image Analysis for use in Online Quantification of Drugs in Dried Sample Spots
Wednesday, 30 May 2012 at 16:00
The complete automation of sample preparation and analysis for dried blood spots (DBS) has ignited new interest in this form of biosampling. This talk illustrates how reproducibility and data integrity features were realized by virtue of digital imaging in Prolab's SCAP DBS System.
