Ye Ai,
Associate Professor,
Singapore University of Technology and Design
Dr. Ye Ai is currently an Associate Professor at Singapore University of Technology and Design (SUTD) since 2013. He obtained his B.S. in Mechanical Engineering from Huazhong University of Science and Technology (China) in 2005 and his Ph.D. in Mechanical and Aerospace Engineering from Old Dominion University (USA) in 2011. Prior to joining SUTD, he worked as a postdoctoral researcher at the Bioscience Division of Los Alamos National Laboratory from June 2011 to January 2013. He was a visiting professor at Massachusetts Institute of Technology from August 2014 to July 2015. His research interest focuses on developing novel microfluidic technologies for particle/cell manipulation and single cell analysis. He has published more than 60 peer-reviewed scientific papers in leading international journals including Physical Review Letters, Science Advances, Lab on a Chip, Nanoscale, Biosensors and Bioelectronics, Analytical Chemistry and Microsystems & Nanoengineering.
Precise Cell Manipulation Using Highly Focused Acoustic Fields
Thursday, 14 November 2019 at 16:30
Add to Calendar ▼2019-11-14 16:30:002019-11-14 17:30:00Europe/LondonPrecise Cell Manipulation Using Highly Focused Acoustic FieldsMicrofluidics and Organ-on-a-Chip Asia 2019 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com
Precise manipulation of particles and biological cells is an essential process in various biomedical research fields, industrial and clinical applications. Among various force fields applied for microfluidic cell manipulation, acoustic waves have superior propagating properties in solids and fluids, which can readily enable non-contact cell manipulation in long operating distances. In addition, acoustic fields are advantageous to high power laser beams for non-contact optical tweezing in terms of biocompatibility, throughput and setup simplicity. Exploiting acoustic waves for fluid and cell manipulation in microfluidics has led to a newly emerging research area, acoustofluidics. In this presentation, I will talk about particle and cell manipulation in microfluidics using highly focused surface acoustic waves (SAW). In particular, I will discuss a unique design of a focused interdigital transducer (FIDT) structure, which is able to generate a highly localized SAW field on the order of 30-50 µm wide. This highly focused acoustic beam has an effective manipulation area size that is comparable to individual micron-sized particles. Here, I demonstrate the use of this highly localized SAW field for fluorescence activated single cell level sorting with high cell viability.
