SELECTBIO - Liquid Biopsies 2019 Biographies

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Ultra-Sensitive Mutational Analysis in Cell-Free DNA by Digital PCR and NGS Technologies

Wednesday, 27 March 2019 at 15:00

Add to Calendar ▼2019-03-27 15:00:002019-03-27 16:00:00Europe/LondonUltra-Sensitive Mutational Analysis in Cell-Free DNA by Digital PCR and NGS TechnologiesLiquid Biopsies 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com

Circulating cell-free DNA (cfDNA) in plasma offers a non-invasive approach to monitor tumor molecular profiling in real-time at multiple time-points, detection of emerging genomic alterations associated with drug resistance and clarifying cancer prognosis and diagnosis of cancer recurrence or progression. We developed an ultra-sensitive droplet digital PCR (ddPCR) approach and molecular tagged NGS technologies to detect actionable cancer biomarkers in cfDNA.

Rachel Tam, Senior Scientific Researcher, Oncology Biomarker Development, Genentech

Rachel Tam has been working in Genentech as senior scientific researcher for 8 years. She is a technical expert on multiple molecular biology technologies including qPCR, ddPCR and NGS. She has developed a high throughput multiplex microfluidics qPCR platform to detect mutations in fresh frozen, FFPE, TMA and cell free DNA samples from multiple clinical trials routinely. Recently, she has been developing ultra-sensitive assays utilizing ddPCR and NGS technologies to detect mutations from circulating tumour DNA, paving the way to develop personalized medicine for cancer patients.