Engineering Organotypic Disease On-a-Chip Models; Harnessing Innovations in Microfluidics, Biomaterials and Single-Cell Resolution Analysis

Thursday, 30 November 2023 at 08:30

Add to Calendar ▼2023-11-30 08:30:002023-11-30 09:30:00Europe/LondonEngineering Organotypic Disease On-a-Chip Models; Harnessing Innovations in Microfluidics, Biomaterials and Single-Cell Resolution AnalysisLab-on-a-Chip and Microfluidics World Congress 2023 in Laguna Hills, CaliforniaLaguna Hills,

Three-dimensional (3D) ex vivo organotypic tissue models have garnered significant attention for a wide range of applications in the landscape of biomedical and pre-clinical research. Tissue-on-a-chip technologies have effectively addressed the limitations associated with animal models, providing a better understanding of the intricate biological mechanisms underlying complex human diseases. These innovative technologies have also greatly streamlined the drug development and discovery process by establishing scalable and high-throughput miniaturized platforms for efficiently assessing the effectiveness of multiple drugs and compounds. In this seminar, Dr. Nikkhah will introduce his laboratory's multidisciplinary research focus, which centers on the integration of microfluidics technologies, advanced biomaterials, and single-cell level analysis to create the next generation of physiologically relevant organotypic tissue-on-chip platforms for disease modeling and drug testing applications. The seminar will particularly highlight their work in engineering tumor microenvironment (TME) models, aimed at studying the earliest stages of cancer progression in the metastatic cascade. Additionally, he will briefly touch upon the development of a 3D vascularized human stem cell-derived tissue-on-a-chip model designed for investigating cardiovascular and cerebrovascular diseases.

Mehdi Nikkhah, Associate Professor of Bioengineering, Arizona State University

Mehdi Nikkhah

Mehdi Nikkhah is currently an Associate Professor of Biomedical Engineering at the School of Biological and Health Systems Engineering (SBHSE), Arizona State University (ASU). He completed his postdoctoral fellowship training at Harvard Medical School and Brigham and Women’s Hospital. He received his B.S. in mechanical engineering and M.S. degree in biomedical engineering from Tehran Polytechnic University followed by Ph.D. degree in mechanical engineering from Virginia Tech. His lab’s research interest is focused on the integration of micro- and nano-scale technologies, innovative biomaterials, and biology to better understand the mechanisms of human disease progression and to develop regenerative medicine strategies for treatment of organ/tissue failure. Dr. Nikkhah has published more than 75 journal articles (+10,000 citations, H-index of 46), 8 book chapters and 95 peer-reviewed conference papers and holds 10 US patents and invention disclosures. He has received numerous prestigious awards and recognitions during his career including National Academy of Inventors Senior Membership, Arizona Flinn Foundation Award, ASU Biomedical Engineering Outstanding Assistant Professor Award, NSF CAREER Award and so forth. Along with his research endeavors, Dr. Nikkhah is also very passionate to educate the next generation of students and scholars, with specific attention to minority and underrepresented groups, in science and engineering. He has trained more than 65 trainees including postdoctoral fellows, PhD/MS students as well as undergraduate researchers, from a diverse background, in his lab.