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Fundamental Consideration Points For the Liver Organ-on-a-Chip

Friday, 15 November 2019 at 10:30

Add to Calendar ▼2019-11-15 10:30:002019-11-15 11:30:00Europe/LondonFundamental Consideration Points For the Liver Organ-on-a-ChipMicrofluidics and Organ-on-a-Chip Asia 2019 in Tokyo, JapanTokyo, JapanSELECTBIOenquiries@selectbiosciences.com

Hepatocytes, the main parenchymal cell in the liver, has many functions and is widely used in in vitro cell-based assays. However, maintaining their physiological function is not easy. Same is the case for hepatic stellate cells, which are involved in hepatic fibrosis. Reconstitution of complicated physiological structure of the liver is thought to be necessary to reproduce adequate hepatic functions in in vitro culture model. Liver organ-on-a-chip is expected to solve these difficulties. Fundamental consideration points for the construction of liver orga-on-a-chip are discussed, with the introductory description of basic liver physiology, in the presentation.

Seiichi Ishida, Section Chief, Division of Pharmacology, National Institute of Health Sciences

Seiichi Ishida is Section Chief at Division of Pharmacology at National Institute of Health Sciences. He received his PhD in Pharmaceutical Science from the University of Tokyo, Japan in 1993, and conducted postdoctoral studies at The Cancer Institute (Tokyo) and at Howard Hughes Medical Institute at Duke University Medical Centre. His research focuses primarily on the development of in vitro cell assay platform for the evaluation of drug metabolism and drug induced liver injury and their application to the regulatory science field.