Valeria Orlova,
Dr. Orlova is recognised for her research on hiPSC applications to cardiovascular biology, disease modelling and blood vessels in organ-on-chip devices. She has a strong background in vascular biology with expertise that includes differentiation of endothelial cells, pericytes, vascular smooth muscle cells and inflammatory cells from hPSCs, assays for functional chararcterization of hPSC-derived vascular cells (inflammatory responses, barrier function, high-content intracellular Ca2+ release), photopatterning technology to design cell substrates, RNAseq and methods for 3D analysis of hiPSC-EC vessels in OoCs. Orlova coordinates a large interdisciplinary consortium funded by the Dutch Research Agenda: Research on Routes by Consortia (NWA-ORC 2019) in which ‘organ-on-chip' models for the lymphatic and immune system are being built using hiPSC as a precision tool to investigate immune system-related disorders.
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