Cleber Trujillo,
Project Scientist
Since 2001, I have investigated the role of neurotransmitters in neural physiology and development. Using mouse and human neural stem cells as model systems and in combination with a state-of-art molecular and cellular techniques, I explored novel pathways and therapeutic targets for neurodevelopmental disorders, including autism, and Rett Syndrome. While studying neurogenesis and neurotransmission signaling at the University of São Paulo, I developed an interest in modeling neurodevelopmental disorders. At the University of California – San Diego (2011), I took advantage of reprogramming technologies to generate iPSCs to recapitulate early stages of the human MECP2 Duplication Syndrome, showing a promising cellular tool to facilitate therapeutic drug screening for severe neurodevelopmental disorders. The iPSC model was also used to fill in the current knowledge gap in Williams Syndrome cellular biology and lead to further insights into the molecular mechanism underlying the disorder and the human social brain. Currently, I am a Project Scientist at the UCSD studying the formation of human network using brain organoids during development and disease conditions.
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