Eric Martin,
Director, Computational Chemistry
Eric Martin has a Ph.D. in physical organic chemistry from Yale University. He has worked in computational drug design and herbicide design for over 30 years. Eric is best known for starting the now widely practiced field of combinatorial library design. He is currently developing novel methodologies for two areas of drug discovery: rational oral bioavailability design and protein-family virtual screening (PFVS). The former guides improvement of oral exposure during lead optimization by applying global sensitivity analysis to physiologically-based pharmacokinetics simulations (GSA of PBPK). PFVS computer models achieve accuracy comparable to experimental high throughput screening by combining all historical activity data from entire protein families, work for which Eric was awarded the lifetime title of Novartis Leading Scientist.
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