Guillaume Van Niel,
Team leader Endosomal Dynamic in Neuropathies
Since 1998, Guillaume van Niel has investigated exosomes and their compartment of origin, multivesicular bodies. During his Ph.D at the Necker institute (Paris, France), he reported and investigated the secretion and the function of exosomes secreted by intestinal epithelial cells. In 2003 at the Utrecht medial center (Utrecht, the Netherlands) he demonstrated ubiquitination of MHC II molecules, a key post-translational modification for sorting to multivesicular bodies in dendritic cells. In 2005 he joined the Curie Institute (Paris, France) and obtained a CNRS permanent position in this team in 2008 to investigate the biogenesis of multivesicular bodies in pigment cells. He notably reported the role of intraluminal vesicles in the generation of physiological amyloid fibrils. Since 2017 he is team leader at the Center of Psychiatry and Neurosciences (Paris, France) and research Director at CNRS. He is using his strong expertise in the cell biology of exosomes and in different technics of electron and light microscopy imaging to develop new tools to visualize exosomes, notably in vivo, and to understand the role of the endosomal dynamic in amyloid associated pathologies.
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