Shyam Prabhakar,
Associate Director/Integrative Genomics and Group Leader
Shyam Prabhakar obtained a B.Tech in Engineering from the Indian Institute of Technology, Madras and a PhD in Applied Physics from Stanford University. He was the sole recipient of the American Physical Society Award for Outstanding Doctoral Thesis Research in Beam Physics in 2001. As a postdoctoral fellow under Eddy Rubin at the Lawrence Berkeley National Laboratory, he developed algorithms for detecting transcriptional enhancers active during mammalian development, and discovered the first known human-specific developmental enhancer. His group at the Genome Institute of Singapore performs large-scale analyses of epigenome dynamics and single-cell functional states to understand the molecular mechanisms of autism, lung and colon cancer, autoimmune disorders and human development. Major achievements include the first comprehensive study of genetic variants that affect histone acetylation, the first genome-wide analysis of anthropoid primate-specific functional elements and the first unified signal-processing method for peak detection in whole-genome functional profiling data.
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