Poster Presentations
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Rapid Studies of Rhodium-Catalyzed Hydroformylation Reactions Enabled by an Automated Single-Droplet Flow Reactor
KESHAV RAGHUVANSHI, Post-Doc Research Associate, North Carolina state university
Abstract: Rhodium catalyzed hydroformylation of alkenes has evolved from being considered as an academic chemical synthesis toolbox to the largest industrial application of homogeneous catalysis. Ligands play a significant role in tailoring the selectivity and yield of the aldehyde products. In recent years, flow chemistry has emerged as a material and time-efficient approach for studies of single/multi-phase catalytic reactions. [1] In this work, an automated flow chemistry platform using a tube-in-tube single-droplet flow reactor is designed and developed for rapid library screening of phosphine-based ligands in hydroformylation of alkenes. [2] The inner tube of the single-droplet flow reactor is a permeable Teflon membrane with a high syngas permeability. The outer tube of the flow reactor is a clear Teflon tube (fluorinated ethylene propylene). The oscillatory motion of the single droplet containing the reaction mixture (i.e., Rhodium catalyst, solvent, substrate, and dissolved syngas) removes the heat and mass transfer limitations associated with conventional autoclaves. The developed flow chemistry platform enables precise process control as well as rapid screening of the effect of reaction parameters (e.g., reaction time, temperature, syngas pressure/composition, and suitable ligand) on the chemo- and regio-selectivity of the produced aldehydes
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