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Held in conjunction with Lab-on-a-Chip & Microfluidics 2016
14 Mar 2016, at 13:30 in Madrid, Spain
Who should attend? The ‘crash-course’ is aimed at professionals, students, scientists, technicians and engineers who would like to learn (more) about lab-on-a-chip devices and their applications in the area of bioanalysis and life sciences. Researchers who are interested in working with microfluidic devices will acquire a comprehensive overview of the field. The course will also provide an opportunity for researchers who already have experience with microfluidic devices but who would like to update or broaden their knowledge on recent developments in bio-applications. Learning Objectives 1. Understand the benefits and limitations of miniaturisation and learn how lab-on-a-chip devices can be fabricated, assembled and operated. 2. Understand the behaviour of fluids in microchannels and learn how this has led to methods of pumping, mixing and detection that can be quite different from those used on the larger scale. 3. Gain a broad overview over the applications of lab-on-a-chip devices in the area of life sciences including DNA and protein analysis as well as recent developments in cell and tissue analysis. 4. Understand the challenges and recent developments towards integrated and portable analysis systems (microTAS) that can be used at the point-of-care for medical applications, at-the-scene for forensic applications or in-the-field for environmental and biodefence applications. Topics and Course Organisation Principles of Microfluidics and Construction of microTAS 1. Benefits of miniaturising fluid handling challenges for bioanalysis today and how they can be addressed by lab-on-a-chip technology 2. Fabrication of Microfluidic Devices overview of materials, fabrication processes and interfacing strategies 3. Flow behaviour in microchannels laminar and turbulent flow, diffusion, multi-phase flow with example applications 4. Handling of fluids components for fluid handling including pumps, mixers and valves 5. Detection in microfluidic devices suitable detection methods at the microscale including spectroscopy and electrochemical methods Applications of Microfluidic Devices in Bioanalysis 1. DNA analysis on-chip DNA extraction, PCR and separation as well as hybridisation assays,; case study: forensic DNA analysis 2. Protein analysis on-chip immunoassays, lateral flow assays, pre-concentration, separation; case study: point–of-care analysis of cardiac markers 3. Cell and tissue analysis handling of single cells and cell arrays, analysis with living tissue slices, handling of living organisms case study: organs-on-chip and human-on-a-chip to replace animal testing 4. Integrated devices for point-of-care or in-the-field analysis focussing on microfluidic devices for point-of-care applications
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