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3 for 2 Offer SELECTBIO Conferences Emerging Role of Next Generation Sequencing in Clinical GenomicsNanoSciTech 2017The RNA Summit: Research, Diagnostics & TherapeuticsNext Generation Sequencing in the Clinic Asia 2017Lab-on-a-Chip & Microfluidics, Point-of-Care Diagnostics & Global Health Asia 2017ePoster Award Prize

Lab-on-a-chip for Life Science Applications

Held in conjunction with Lab-on-a-Chip & Microfluidics 2016

14 Mar 2016, at 13:30 in Madrid, Spain


Who should attend?

The ‘crash-course’ is aimed at professionals, students, scientists, technicians and engineers who would like to learn (more) about lab-on-a-chip devices and their applications in the area of bioanalysis and life sciences. Researchers who are interested in working with microfluidic devices will acquire a comprehensive overview of the field. The course will also provide an opportunity for researchers who already have experience with microfluidic devices but who would like to update or broaden their knowledge on recent developments in bio-applications.

Learning Objectives

1. Understand the benefits and limitations of miniaturisation and learn how lab-on-a-chip devices can be fabricated, assembled and operated.

2. Understand the behaviour of fluids in microchannels and learn how this has led to methods of pumping, mixing and detection that can be quite different from those used on the larger scale.

3. Gain a broad overview over the applications of lab-on-a-chip devices in the area of life sciences including DNA and protein analysis as well as recent developments in cell and tissue analysis.

4. Understand the challenges and recent developments towards integrated and portable analysis systems (microTAS) that can be used at the point-of-care for medical applications, at-the-scene for forensic applications or in-the-field for environmental and biodefence applications.

Topics and Course Organisation

Principles of Microfluidics and Construction of microTAS

1. Benefits of miniaturising fluid handling

challenges for bioanalysis today 

and how they can be addressed by lab-on-a-chip technology

2. Fabrication of Microfluidic Devices

overview of materials, fabrication processes and interfacing strategies

3. Flow behaviour in microchannels

laminar and turbulent flow, diffusion, multi-phase flow

with example applications

4. Handling of fluids 

components for fluid handling including pumps, mixers and valves

5. Detection in microfluidic devices

suitable detection methods at the microscale

including spectroscopy and electrochemical methods

Applications of Microfluidic Devices in Bioanalysis

1. DNA analysis

on-chip DNA extraction, PCR and separation as well as hybridisation assays,; case study: forensic DNA analysis

2. Protein analysis

on-chip immunoassays, lateral flow assays, pre-concentration, separation; case study: point–of-care analysis of cardiac markers

3. Cell and tissue analysis

handling of single cells and cell arrays, analysis with living tissue slices, handling of living organisms 

case study: organs-on-chip and human-on-a-chip to replace animal testing

4. Integrated devices for point-of-care or in-the-field analysis

focussing on microfluidic devices for point-of-care applications

Nicole Pamme

Nicole Pamme, Professor, The University of Hull