Organ-on-a-Chip Europe 2017 Agenda

Registration

Biomaterials Design for Experimental Organ Models
Gianluca Ciardelli, Professor, Polytechnic University of Turin, Italy

Engineered tissue models offer new options for a better understanding of disease progress and the development of new treatments. In this work biomimetic scaffolds are proposed as innovative myocardial and bone models.

Translational Applications of Microphysiological Systems (MPS)
Murat Cirit, Director at Translational Center of Tissue Chip Technologies, Massachusetts Institute of Technology (MIT), United States of America

Systems pharmacology approaches to microphysiological systems (MPS) enable mechanistic data interpretation and, hence, in vitro in vivo translation (IVIVT) of pharmacokinetics, pharmacodynamics and patient specific response biomarkers.

Coffee & Networking in Exhibition Hall

Extracellular Matrix Mimetic Hydrogels of Natural Polymers for Organ-on-chip Applications
Marcel Karperien, Professor, University of Twente, Netherlands

In this presentation I will describe our strategy to develop chemically defined substitutes for matrigel that can be applied in organ-on-chip models for formation of functional microtissues.

A New Cells-On-A-Chip Based on Vinyl Development for Real-Time Skin Monitoring
Miguel Holgado Bolaños, Group Leader, Universidad Politécnica de Madrid, Spain

This talk will present a new disposable biochip based on Vinyl and PDMS that can mimic skin physiology and architecture.

Biomembrane-on-a-chip
Yan Yan Shery Huang, Lecturer, University of Cambridge, United Kingdom

On-Chip Microvessel Platform for Cancer Invasion Studies.

Lunch & Networking in Exhibition Hall

Poster Viewing Session

Free Workshop
Translating Customers Ideas into Microstructured Smart Polymer Parts Workshop
Iris Bergmair, Head of Sales & Business Development

Technology Spotlight:
Linking the Liver – Interconnected Microphysiological Systems
David Hughes, Chief Technical Officer, CN Bio Innovations Ltd.

Interconnected microphysiological systems often feature a liver model. Research and development relating to linked gut-liver, PBMC-liver and pancreas-liver multi-organ systems will be presented.

Modelling the Eye with Microfluidics
Anderson Shum, Professor, Department of Mechanical Engineering; Director, Advanced Biomedical Instrumentation Centre, University of Hong Kong, Hong Kong

I will discuss our efforts in combining microfluidics and cell-culture to mimic the retinal environment of a human eye, and outline how these could facilitate the development of new surgical procedures.

Coffee and Networking in Exhibition Hall

Advanced Cellular Models in Drug Safety Assessment - An Industry User Perspective
Cristina Bertinetti-Lapatki, Lab Head Mechanistic Safety, Roche Pharma Research & Early Development, F. Hoffmann-La Roche Ltd, Switzerland

Microengineered Physiological Biomimicry: Human Organs-on-chips
Dan Huh, Associate Professor of Bioengineering and Wilf Family Term Endowed Chair, University of Pennsylvania, United States of America

Drinks Reception in Exhibition Hall

End of Day One

Advanced Integrated Optical Oxygen and pH Sensors for Organ on Chip Applications
Torsten Mayr, Associate Professor, Leader-Applied Sensors, Graz University of Technology Austria, Austria

Integrated optical oxygen, pH and glucose sensors are presented enabling monitoring of oxygen and glucose content and pH changes in microfluidic cell cultures or organ on chips with a high precision read-out.

Physiological Scaling and Computational Models for Microfluidics
Arti Ahluwalia, Associate Professor, University of Pisa, Italy

Scaling in organ on a chip systems: how big is too small? A treatise on allometric scaling in-vitro.

Coffee & Networking in Exhibition Hall

Towards High Content Screening Platforms: Parallelizable Microphysiological Systems as In-vitro Models of Cardiac and Adipose Tissue
Peter Loskill, Assistant Professor for Experimental Regenerative Medicine; Attract Group Leader Organ-on-a-Chip, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Eberhard Karls University Tübingen, Germany

Kidney on a Chip using Cell Sheet Engineering
Brian Derby, Professor, University of Manchester, United Kingdom

There is a need for an improved kidney-on-a-chip for applications in toxicity testing and early stage compound screening. The filtration structures in a kidney are thin cell sheets that act as membranes. Here we present a cell sheet concept for a more accurate representation of a kidney for in vitro organ models.

Barrier-on-chip Models using 3D Biological Scaffolds
Maria Tenje, Senior Lecturer, Uppsala University, Sweden

We show the structuring of 3D cell culture scaffolds using natural hydrogels defined in thickness and lateral resolution on the micrometer scale. These materials can serve as the basis of novel in vitro models.

Lunch & Networking in Exhibition Hall

Poster Viewing Session

Free Workshop
The Fast Tracking Medical Diagnostics and Biosensor Technologies to the Market Workshop
Martin Peacock, Director

Technology Spotlight:
High Resolution Flow Control for Physiological Conditions Mimicking
Sebastian Cargou, CEO, Elvesys

The human circulatory system comprises a complex network of blood vessels interconnecting biologically relevant organs and a heart driving blood recirculation throughout this system. Elveflow focuses on the development of high resolution flow controller enabling users to control the mimicked blood pressure and heartbeat rate within a microfluidic circulatory system.

Coffee & Networking in Exhibition Hall

Topologies, Analytics, and Automation for Microphysiological Systems
John Wikswo, Gordon A. Cain University Professor, A.B. Learned Professor of Living State Physics; Founding Director, Vanderbilt Institute for Integrative Biosystems, Vanderbilt University, United States of America

Increased Physiological Relevance of Tumor Cells in Pre-clinical Research: The Pathway for Earlier and Higher Prediction of Drug Efficacy
Vitor Espirito Santo, Researcher, IBET – Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal, Portugal

Tumor microenvironment has an impact in disease progression and drug response. Herein we present a cell model system incorporating microenvironment features of tumor pathophysiology and the potential of this tool for pre-clinical research and drug discovery.

Close of Conference