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SELECTBIO Conferences Point-of-Care, Biosensors and Mobile Diagnostics Europe 2022

Point-of-Care, Biosensors and Mobile Diagnostics Europe 2022 Agenda


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Tuesday, 21 June 2022

00:00

Title to be Confirmed.
Mark Bradley, Professor, Schools of Chemistry and Medicine, University of Edinburgh, United Kingdom

00:00

Emmanuel DelamarcheKeynote Presentation

Title to be Confirmed.
Emmanuel Delamarche, Manager Precision Diagnostics, IBM Research - Zürich, Switzerland

00:00

Peter ErtlKeynote Presentation

Title to be Confirmed.
Peter Ertl, Professor of Lab-on-a-Chip Systems, Vienna University of Technology, Austria

00:00

Karolien De WaelKeynote Presentation

Singlet Oxygen-Based Photoelectrochemical DNA Sensing
Karolien De Wael, Full Professor, Antwerp University, Belgium

To avoid the main drawback of semiconductor-based photoelectrochemical (PEC) systems, i.e. the uncontrollable nature of photo-induced charge or electron transfer processes, a novel and innovative PEC sensing paradigm has been introduced. The sensing paradigm is based on the unique feature of type II molecular photosensitizers to transfer the excitation energy to oxygen generating 1O2. Indeed, the action is initiated by the absorption of a photon to yield an excited sensitizer. Reactions of the excited sensitizer can involve Type I or Type II reactions via intersystem crossing. The latter involves an energy transfer from the excited photosensitizer to O2 to yield 1O2 and is of particular interest for our paradigm. It will be a matter of minimizing or controlling the contribution of Type I reactions in the mechanism through the selection of the photosensitizer or the use of quenchers. The Type II photosensitizers can also be used as molecular labels coupled to specific DNA sequences for highly sensitive and cost-efficient photoelectrochemical DNA sensing applications. In this lecture, the sensing mechanism will be explained together with the photoelectrochemical properties of molecular photosensitizers used as labels for biomolecules. The photocatalytic activity of different photosensitizers in solution and attached to ssDNA have been evaluated in the absence and presence of a redox reporter (hydroquinone). Both type I and type II photosentiziers were studied. In particular, a porphyrin chlorin e6 was found to give a well-detectable photocurrent response in solution or as a label attached to ssDNA. With an intrinsic background elimination by switching the light ON/OFF, this photoelectrochemical strategy provides enhanced sensitivity. The quantification of prostate cancer related miRNAs in human serum will be discussed, and positioned towards electrochemiluminescent assays.

00:00

Holger SchmidtKeynote Presentation

Title to be Confirmed.
Holger Schmidt, Narinder Kapany Professor of Electrical Engineering, University of California-Santa Cruz, United States of America

00:00

Title to be Confirmed.
John Brennan, Professor and Director, Biointerfaces Institute, McMaster University, Canada

00:00

Marloes PeetersKeynote Presentation

Biomimetic Sensor Platforms for the Thermoelectric Detection of Biomarkers and Viruses
Marloes Peeters, Deputy Director of Chemical Engineering, Newcastle University, United Kingdom

We will demonstrate that a novel functionalized interface, where molecularly imprinted nanoparticles (nanoMIPs) are attached to screen-printed graphite electrodes (SPEs), can be utilized for the thermo-electric detection of biomarkers, such as troponin, and viruses, including norovirus. Our developed platform presents an innovative route to develop accurate, low-cost, and disposable sensors for the the diagnosis of diseases. A reproducible and advantageous solid-phase approach was utilized to synthesize high affinity nanoMIPs; these synthetic receptors are able to compete with antibodies in terms of affinity and selectivity. Subsequently, several approaches were assessed to immobilize the nanoMIPs onto the electrode surfaces, varying from dip coating, to dropcasting, to covalent electrografting. Characterization of the nanoMIP-functionalized surfaces with electrochemical impedance spectroscopy, atomic force microscopy and scanning electron microscopy revealed that  covalent functionalization of the SPEs led to the sensors with the highest and most reproducible sensing capabilities. Proof-of-application in buffered solutions demonstrated detection based of electrochemical sensing and monitoring of changes in heat-transfer at the solid-liquid interface enabled detection in the pg range, which is physiologically relevant. Furthermore, a side by side comparison of testing with antibodies showed a 20-fold improvement in signal. In the future, we aim to redevelop our sensor design to a new addition cell with sample volumes as small as a blood drop (20 microL) and measurement times <5 min. Due to the versatility of the nanoMIPs in combination with the reproducible and low-cost nature of the SPEs, show this sensor platform technology has a clear commercial route with high potential to contribute to sustainable healthcare.

00:00

Title to be Confirmed.
Jean-Manuel Segura, Professor, University of Applied Sciences and Arts Western Switzerland Valais, Switzerland


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Add to Calendar ▼2022-06-21 00:00:002022-06-22 00:00:00Europe/LondonPoint-of-Care, Biosensors and Mobile Diagnostics Europe 2022Point-of-Care, Biosensors and Mobile Diagnostics Europe 2022 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com