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SELECTBIO Conferences Point-of-Care Diagnostics & Biosensors Europe 2018

Point-of-Care Diagnostics & Biosensors Europe 2018 Agenda

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Tuesday, 5 June 2018


Drug Quantification in Whole Blood within Micro-Devices for Point-of-Care Therapeutic Drug Monitoring
Jean-Manuel Segura, Professor, University of Applied Sciences and Arts Western Switzerland Valais, Switzerland


John BrennanKeynote Presentation

Integrating Aptamer Technology with Paper-Based Point-of-Care Devices for Biomedical Monitoring
John Brennan, Professor and Director, Biointerfaces Institute, McMaster University, Canada

The talk will focus on the development of printed point-of-care paper sensors with integrated aptamer-based recognition, amplification and signaling technologies for detection of a range of clinical analytes.  Examples will be provided to demonstrate multi-step reactions on paper for ultra-sensitive detection of infectious organisms and cancer biomarkers.


Jong Wook HongKeynote Presentation

Novel Isolate of Extracellular Nanovesicles
Jong Wook Hong, Professor of Bionano Technology and Bionano Engineering, Hanyang University, Korea South

Extracellular vesicles (EVs) are the cell-secreted nano- and micro-sized particles consisted of lipid bilayer containing nucleic acids and proteins for diagnosis and therapeutic applications. The inherent complexity of EVs is a source of heterogeneity in various potential applications of the biological nanovesicles including analysis. To diminish heterogeneity, EV should be isolated and separated according to their sizes and cargos. However, current technologies do not meet the requirements. Here we introduce new way that provides noninvasive and precise separation of EVs based on their sizes without any recognizable damages. We believe the system and methodology would open new windows in precision medicine and personalized medicine.


Molecular Motors and Cytoskeletal Filaments in Biosensing and Parallel Biological Computation
Alf Månsson, Professor, Linnaeus University and Lund University Sweden, Sweden

Actin and myosin are the contractile proteins underlying muscle contraction and key aspects of motile phenomena in non-muscular cells. Here, I report how isolated contractile proteins are used on flat surfaces and in nanofabricated networks for applications in biosensing and biocomputation. More specifically, the motor system underlies transportation of analytes for biocomputation, nanoseparation and concentration at a nanoscale detector as well as biomarker-detection by aggregation of actin filaments.


Emmanuel DelamarcheKeynote Presentation

Point-of-Care Diagnostics 2.0
Emmanuel Delamarche, Manager Precision Diagnostics, IBM Research - Zurich, Switzerland

Diagnostics are ubiquitous in healthcare because they support prevention, diagnosis and treatment of diseases. Specifically, point-of-care diagnostics are particularly attractive for identifying diseases near patients, quickly, and in many settings and scenarios. One of our contribution to the field of microfluidics is the development of capillary-driven microfluidic chips for highly miniaturized immunoassays. In this presentation, I will review how to program capillary flow and encode specific functions to form microfluidic elements that can easily be assembled into self-powered devices for immunoassays, reaching unprecedented levels of precision for manipulating samples and reagents. This technology can also be augmented using peripherals and smartphones for flow control and monitoring with sub-nanoliter precision. Is the next generation of point-of-care devices finally coming?


John McDevittKeynote Presentation

Title to be Confirmed
John McDevitt, Chair, Department Biomaterials, New York University College of Dentistry Bioengineering Institute, United States of America


Using Lasers to Create Affordable Point-of-Care Diagnostic Solutions on Paper Platforms
Collin Sones, Principal Research Fellow/ Associate Professor, University of Southampton, United Kingdom

The talk will summarize the group’s work relating to the field of affordable point-of-care diagnostic devices on porous materials such as paper. The presentation will detail the use of  unique laser-based direct-write technique developed to pattern microfluidic devices in paper and paper-like materials, and will further explain how this platform-technology lends to the incorporation of the various newer attributes to the ever popular paper-based analytical devices and the widely used lateral flow devices or dipsticks.


Arben MerkoçiKeynote Presentation

Title to be Confirmed
Arben Merkoçi, ICREA Research Professor And Group Leader, Catalan Institute of Nanoscience And Nanotechnology, Spain


Eloisa Lopez-CalleKeynote Presentation

A New Platform for Point-of-Care Testing of Cardiac Biomarkers Meeting Current Guidelines
Eloisa Lopez-Calle, Research & Development Line Manager & Development Lead, Roche Diagnostics GmbH, Germany

Cardiovascular diseases, such as acute myocardial infarction (AMI) and heart failure (HF), are the leading cause of death globally. A rapid and accurate diagnosis of these diseases is crucial for the immediate initiation of the treatment for the patients; and biomarkers, such as troponin and NT-proBNP, received the highest clinical guideline recommendation for that use. The measurement of these biomarkers with point-of-care (POC) devices has the unique benefits to (i) reduce the turn-around-time compared to laboratory testing, by avoiding the time-consuming process of sample transportation and pre-analytics (plasma/serum generation), (ii) to use it in the pre-hospital, ambulance settings, and (iii) to rule-out AMI/HF faster, thus allowing an improved flow of patients through the emergency department. Today, however, only few of the commercially available POC-systems show a guideline-compliant analytical performance for troponin testing, which is a recommended imprecision (coefficient of variation, CV) of <10% at the clinical cutoff, given as the 99th percentile upper reference limit of a healthy population.  We have developed an easy-to-use and portable prototype platform for the POC-testing of cardiac troponin T (cTnT) and NT-proBNP using a 30 µL whole blood sample with a time-to-result of 12 minutes or less. The immunoassay is run in a ready-to-use disposable cartridge with fully integrated reagents. After sample application of whole blood, plasma is generated by centrifugation, followed by incubation with immuno-reagents and washing. Finally, the fluorescence is measured, followed by calculating the biomarker amount. This presentation shows features of the new, CLIA-waivable platform matching with POC settings as well as the proof-of-concept for the guideline-compliant determination of cTnT and NT-proBNP with lab-like performance (cTnT: 3.8% as CV at the cutoff (14 ng/L), 6.8 ng/L as functional sensitivity (CV<10%), 8300 ng/L as upper-end measuring range; NT-proBNP:  4.1% as CV at 125 pg/mL-cutoff, 23 pg/mL as functional sensitivity, upper-end measuring range: 17000 pg/mL; excellent correlation of both assays with the commercial Elecsys® tests, hs-TnT 5th Gen. and proBNP II).


Title to be Confirmed
Jane Brock, Assistant Professor, Harvard Medical School; Medical Director Surgical Pathology Grossing Room and Associate Pathologist, Brigham & Women's Hospital, United States of America

Agenda is not currently available
Add to Calendar ▼2018-06-05 00:00:002018-06-06 00:00:00Europe/LondonPoint-of-Care Diagnostics and Biosensors Europe 2018Point-of-Care Diagnostics and Biosensors Europe 2018 in Rotterdam, The NetherlandsRotterdam, The