Flow Chemistry Asia Agenda

Flow in Life Science Product Manufacturing
David Ager, Principal Scientist, DSM Pharma Chemicals, United States of America

* Canx - Due to ill heath *

Flow chemistry is becoming established as the preferred method for reactions where safety, either due to large exotherms or hazardous intermediates, is paramount. A number of different examples will be given.

Coffee Break and Networking

Future Manufacturing Concepts for the Chemical and Pharmaceutical Industry - From Lab to Production
Olaf Stange, Researcher, Bayer Technology Services, Singapore

Flow Chemistry on the basis of process intensification, has become an important topic in the fields of chemical and pharmaceutical industry. The presentation will illustrate how scale up effort and time to market can be reduced when moving from lab to production scale.

Flow Chemistry at Scale – A Processing Approach
Paul Sharratt, Program Manager, Institute Of Chemical And Engineering Sciences (ICES), Singapore

Flow processing at scale can bring benefits but is not a panacea. We discuss when and how flow processing can usefully be deployed for manufacture and illustrate with examples of pilot scale (up to 20L/h) processing.

Lunch, Poster Viewing and Networking

Asymmetric Strecker Reaction Under Continuous Flow on Self-Supported Chiral Titanium Catalyst
Balamurugan Ramalingam, Scientist, Institute of Chemical and Engineering Sciences A*Star, Singapore

A robust self-supported chiral heterogeneous catalyst was synthesized from readily available titanium alkoxide and chiral aminoalcohol ligands. The extreme stability and recyclability of the catalyst enabled us to carry out the cyanation under continuous flow. The complete optimization and advantage of flow methods in improving the enantioselectivity of alphatic branched aldehydes will be presented.

Pd-Catalyzed Cross-Coupling of Aryllithiums with Aryl and Vinyl Halides in an Integrated Flow Microreactor System
Yuya Moriwaki, PhD Student, Kyoto University, Japan

Pd-catalyzed cross-coupling of aryllithiums with aryl and vinyl halides was successfully accomplished by using a flow microreactor system. Space integration of lithiation and Murahashi coupling enabled the rapid cross-coupling of two different aryl halides.

Coffee Break and Networking

Innovative Chemical Processing in CSIRO
John Tsanaktsidis, Senior Principle Research Scientist, CSIRO, Australia

Continuous flow processing (CFP) using tubular reactors represents an emergent paradigm for innovative chemical processing that is poised to change commercial chemical manufacturing. This presentation will outline CSIRO’s capability in CFP and will provide representative examples in small molecule and polymer synthesis.  

Development of Chemical Apparatus Inspired by Microreaction Technology
Ken-Ichiro Sotowa, Professor, University of Tokushima, Japan

Modular structure as well as small characteristic length is an essentially important feature of microreactors.  This observation has been exploited to develop several new chemical apparatus, which do not always fall into the category of microreactors.

Accessing New Chemical Space Using Flow Chemistry-Industry’s Answer To New Compounds?
Richard Jones, Chief Commercial Officer, ThalesNano Nanotechnology Inc, Hungary

This presentation will focus on how flow chemistry at high temperatures and short residence times can synthesize biologically important novel bicyclic heterocycles not possible under standard lab conditions.

Drinks Reception

Renaissance of Traditional Transformations Under Microfluidic Conditions: Practical Synthesis of Biofunctional Natural Products
Katsunori Tanaka, Associate Chief Scientist, RIKEN, Advanced Science Institute, Japan

Our microfluidic examples provoke the need to reinvestigate the traditional but notorious transformations, which have so far been evaluated only in batch apparatus. We report a new strategy in synthesizing the biologically important natural products in a practical and industrial manner.

Coffee Break and Networking

Microfluidic Reaction Engineering of Metal Based Nanomaterials Syntheses
Saif Khan, Associate Professor, Chemical and Biomolecular Engineering, National University of Singapore, Singapore

We present reaction engineering approaches for continuous-flow gold-based nanomaterials syntheses, which leverage the salient features of microfabricated chemical reactors in enabling remarkably controlled multi-phase fluid contacting and spatially and temporally controlled mass transfer processes.

Continuous Flow With Heterogeneous Catalysts Toward Truly Efficient Organic Synthesis
Shu Kobayashi, Professor, Tokyo University, Japan

Several examples of continuous flow systems with heterogeneous catalysts for organic synthesis including selective reduction, oxidation, and asymmetric C-C bond-forming reactions will be described.  

Lunch, Poster Viewing and Networking

Improving the Flow With In Situ, Real Time Analytics
Chai Chien, Product Manager, Mettler-Toledo Autochem, Singapore

Continuous flow chemistry is a relatively new development method for compound generation outside of the chemical and petroleum industries. This presentation focuses on the application of in situ FTIR in continuous flow and the value it brings as a real time reaction information and optimization tool.

Microflow Photochemistry - The 'New' Photochemistry of the Future?
Michael Oelgemöller, Associate Professor, James Cook University, Australia

Coffee Break and Networking

Better Chemical Process Through Lab-on-a-Chip Microreactors
Dong Pyo Kim, Yonsan Chaired Professor, Pohang University of Science And Technology (POSTECH), Korea South

Resistant Lab-on-a-chip microchemical systems fabricated from PDMS, polyimide (PI) film and functional inorganic polymers are demonstrated for various chemical syntheses of organic, polymer and inorganic substances.

Adventures Towards Greener Continuous Flow Chemistry
Ken Lee, Senior Lecturer, Singapore Polytechnic, Singapore

Our group is engaged in continuous flow chemistry, enabling technologies that will provide greener alternatives to the existing chemical syntheses. In this presentation, an overview of our work on ultrasound-assisted and dual Pd-Cu reactor continuous flow chemistries will be provided.

Close of Conference