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SELECTBIO Conferences Flow Chemistry Congress 2016

Flow Chemistry Congress 2016 Agenda

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Wednesday, 2 November 2016


Breakfast & Registration

Day 1: Session Chair
Session Chair: Aaron Beeler, Assistant Professor, Boston University, United States of America


Welcome Address from the Flow Chemistry Society
Ferenc Darvas, Chairman, Flow Chemistry Society, Switzerland


Shawn CollinsConference Chair

Macrocyclization in Continuous Flow
Shawn Collins, Full Professor, Université de Montréal, Canada

The development of various strategies to enable macrocyclization of natural products and pharmaceuticals in continuous flow will be described.


The Application of Flow Chemistry to the Manufacturing Route for MK8931
John Naber, Director, Flow Chemistry and Lab Automation, Process Research & Development, Merck & Co, United States of America

The development of a key step in the synthesis of Merck’s Phase III compound for Alzheimer’s disease from an initial lab scale hit through to a pilot plant campaign on hundreds of kilograms is presented.


Coffee & Networking in the Exhibition Hall


Accelerated C–H Activation Chemistry in Flow Microreactors
Timothy Noël, Professor, University of Amsterdam, Netherlands

Our group has focused on the development of more efficient C–H activation to establish carbon-carbon bonds, including the alkenylation and arylation of indoles and cross-dehydrogenative coupling reactions.


Shading Synthesis Green Using Enabling Technologies
Duncan Browne, Lecturer in Organic Chemistry, Cardiff University, United Kingdom

In this presentation I will discuss the development of continuous multistep process for the safe generation of diazonium salts followed by a green reduction by vitamin C to the corresponding hydrazines and subsequent cyclocondensation to afford a range of pyrazole products.


Advancing Continuous Processing Through Innovative External Collaborations
Scott May, Senior Research Advisor, Eli Lilly & Co, United States of America

This talk will highlight the results and benefits from several different LIFA and LRAP projects including continuous Asymmetric Hydroformylation, Aerobic Oxidation and Asymmetric Aza-Henry Reactions.


Lunch & Networking in the Exhibition Hall


Award LogoPoster Viewing Session

Award Sponsored by 


Timothy JamisonKeynote Presentation

Synthesis Design through the Lens of Flow Chemistry
Timothy Jamison, Robert R. Taylor Professor and Department Head, Massachusetts Institute of Technology, United States of America

The technical, tactical, and strategic opportunities that flow chemistry offers for synthetic chemistry will be discussed.


Diazomethane without Tears. Or Explosions
C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz, Austria

A simple and robust semi-batch apparatus for the generation of anhydrous solutions of diazomethane on laboratory scale is presented. Diazomethane is produced by base-mediated decomposition of Diazald within a semi-permeable Teflon AF-2400 tubing and subsequently selectively separated from the tubing into a flask.


Coffee & Networking in the Exhibition Hall


Preparative Fluoroalkylation via Visible Light Induced Electron Transfer
Corey Stephenson, Professor of Chemistry, Willard Henry Dow Laboratory, University of Michigan, United States of America

The development of visible light photocatalysis in flow will be presented focusing on radical fluoroalkylation reactions.


Automated Flow Peptide Synthesis: Toward Amide Bonds at Nature’s Pace
Brad Pentelute, Assistant Professor, Massachusetts Institute of Technology, United States of America

Here we describe a rapid flow solid phase peptide synthesis methodology that enables incorporation of an amino acid residue in forty seconds with amide-bond formation taking only five seconds. To demonstrate the broad applicability of this method, it was employed to synthesize hundreds of peptides and proteins.


Enz-Flow – The Union of Continuous Processing and Bioprocessing for Chemical Synthesis
Amanda Evans, Assistant Professor, California State University Fullerton, United States of America

In order to establish new, greener, precedents for generating active pharmaceutical ingredients (APIs), the Evans group is focused on advancing the fusion of continuous processing and bioprocessing technologies, or "Enz-Flow”.


Drinks Reception in the Exhibition Hall


Close of Day 1

Thursday, 3 November 2016


Breakfast & Registration

Day 2: Session Chair
Session Chair: Shawn Collins, Full Professor, Université de Montréal, Canada


Carbon Nanohoops in Continuous Flow
Ramesh Jasti, Associate Professor, Organic, Inorganic, Materials, and Supramolecular Chemistry, University of Oregon, United States of America

The cycloparaphenylenes, or carbon nanohoops, are the smallest possible slices of carbon nanotubes. In this presentation, I will describe my group's development of the key macrocyclization reaction in flow to prepare these materials.


Paul WattsKeynote Presentation

The Use of Continuous Flow to Facilitate Sustainable Fine Chemical and API Manufacturing in Africa
Paul Watts, Distinguished Professor and Research Chair, Nelson Mandela University, South Africa

The talk will address how fine chemicals may be manufactured from natural feedstocks and how APIs such as AIDS medicine may be produced within the country.


Analyzing in Flow
Michael Organ, Professor, York University, Canada

Discussion will focus around the development of in-line sampling and analysis for reaction process optimization and production run monitoring.


Coffee & Networking in the Exhibition Hall


Towards Development of Chemo-Enzymatic Continuous-Flow Strategies for API’s Synthesis
Rodrigo de Souza, Associate Professor, Federal University of Rio De Janeiro, Brazil

Development of Chemo-enzymatic continuous-flow cascade reaction will be presented


Development of Continuous Flow Chemistry Using Online PAT
Matt Bio, President/CEO , Snapdragon Chemistry, United States of America

The integration and use of in-line process monitoring tools to facilitate the discovery and rapid optimization of flow chemistry processes will be discussed through case studies.


Novel Conditions for the Preparation of Diazo Reagents in Flow and their Applications
Andre Charette, Professor, Universite De Montreal, Canada

Diazo compounds are versatile reagents in organic synthesis. A new set of conditions has been developed for their preparation in continuous flow. The diazo reagents are produced in solution free of contaminants that may interfere with the subsequent reactions.


Lunch & Networking in the Exhibition Hall


Award LogoPoster Viewing Session

Award Sponsored by


Aaron BeelerConference Chair

Enabling Synthesis and Medicinal Chemistry with Continuous Flow Reactions
Aaron Beeler, Assistant Professor, Boston University, United States of America

Development of reactions in flow has many advantages, but perhaps the most enabling is the ability to facilitate transformations that are otherwise challenging or impossible. We are working to develop such reactions and apply them to synthesis and medicinal chemistry. This presentation will discuss the optimization and application of photochemical reactions and reactions utilizing highly reactive, short-lived intermediates.


Developing A Compact, Portable 4.7 T Driven NMR System for At-Line Reaction Monitoring
David Strand, President & CEO, Protasis Corporation, United States of America

Historically, chemical reactor control has been challenging because composition measurements are often slow and non-specific. Compact, portable mid-field (200 – 400 MHz) NMR analyzers are now possible and will begin to provide practical composition measurements for research, pilot and production reactors in near-real-time. A first-of-kind, cryogen-free 200 MHz process NMR analyzer is described and initial reactor monitoring results are presented.


Development of Continuous Flow Micro-reactors for Fast Liquid and Liquid-liquid Reactions
Arturo Macchi, Professor of Chemical and Biological Engineering, University of Ottawa, Canada

The reactor design for fast liquid and liquid-liquid reactions was optimized based on the impact of phase physical properties, mixer geometry, method of energy input and scale.


Close of Conference, Coffee & Networking in the Exhibition Hall

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