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SELECTBIO Conferences Flow Chemistry Summit 2021

Flow Chemistry Summit 2021 Agenda

Co-Located Conference Agendas

Flow Chemistry Summit 2021 | 

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Thursday, 30 September 2021


Conference Registration, Materials Pick-Up, Morning Coffee and Pastries


Paul WattsConference Chair

Conference Welcome and Introduction by Conference Chairperson
Paul Watts, Distinguished Professor and Research Chair, Nelson Mandela University, South Africa

Session Title: Emerging Themes and Trends in Flow Chemistry

Session Chairperson: Professor Paul Watts


Klavs JensenKeynote Presentation

Automation, Machine Learning, and Robotics for Flow Chemistry Optimization
Klavs Jensen, Professor, Massachusetts Institute Of Technology, United States of America

Advances in flow chemistry enabled by automation, machine learning, robotics, and on-line analytics  are highlighted through case studies, including an automated droplet microfluidic electrochemistry platform for redox neutral electrochemistry, reaction optimization and characterization of kinetics, (2) an automated cascade of miniaturized continuous stirred tank reactors (CSTRs) for optimization of flow chemistry and photo-redox catalysis involving suspensions of solids, and (3) an automatic, robot assembled, reconfigurable modular micro/mini-fluidic system for execution and optimization of multistep reactions. Machine learning models for retrosynthesis and forward prediction combined with reaction context identification provide computer aided synthesis pathway planning for this system.  We describe and compare different optimization strategies and discuss challenges and opportunities in further integration of machine learning and synthesis platforms.


Timothy JamisonKeynote Presentation

On-Demand Synthesis
Timothy Jamison, Robert R. Taylor Professor and Department Head, Massachusetts Institute of Technology, United States of America

Flow chemistry has had–and will continue to have–many significant impacts on the synthesis of organic molecules.  Flow systems can reduce reaction times, increase efficiency, and obviate problems often encountered in scaling up comparable batch processes.  In addition to these important practical advantages, flow chemistry expands the “toolbox” of organic reactions available to scientists engaged in the synthesis of molecules – from small-scale experiments to large-scale production.  These benefits are a direct result of several features of flow synthesis that batch synthesis typically cannot achieve, for example, the ability to control fluid flow precisely, the access to temperature and pressure regimes not usually considered to be practical, and the enhanced safety characteristics of flow chemical systems.  In this lecture we will discuss some of our investigations in this area in the form of case studies.  By enhancing the design rules for organic synthesis and molecular discovery, flow chemistry therefore represents an important conceptual advance in the design and execution of chemical syntheses.  On-demand synthesis embodies these and other exciting opportunities.


Mid-Morning Coffee Break and Networking


Challenges and Benefits of Implementing Integrated Continuous Manufacturing (ICM) Beyond the Laboratory
Bayan Takizawa, Chief Business Officer, CONTINUUS Pharmaceuticals, Inc., United States of America

Recently, there has been increased interest in the application of continuous manufacturing to pharmaceuticals. The advantages are undeniable, as many other industries have evolved their production systems, enjoying the improved efficiencies and lower costs associated with continuous manufacturing. Pharma, conversely, has been slower to adapt, clinging to outdated batch methods and fragmented supply chains that are vulnerable to disruptions, which ultimately impact patient care. Fortunately, more and more companies are embracing continuous manufacturing, several receiving approvals of continuously produced drug products in recent years. This presentation will focus on some of the challenges in implementing continuous manufacturing in the pharma industry, but also show why change is imminent. Regulatory, quality, cultural, and other relevant factors will be discussed.


Automated Flow Platforms with In-Built Flexibility – Radial Synthesis and Beyond
Kerry Gilmore, Assistant Professor, University of Connecticut, United States of America

Automated flow chemistry platforms have the capability to significantly accelerate and standardize the development and study of organic chemistry reactions and processes. However, one limitation of the general approach is the design of custom systems for specific targets or processes. This requires physical reconfiguration of the system to perform the next “unique” process. By decoupling sequential process steps, an incredible degree of flexibility is introduced into a multistep continuous process. This approach affords numerous capabilities unavailable in a traditional flow system. In this talk, we will discuss how automated platforms using this approach create the opportunity for one-stop systems for fully remote research and data generation.


Networking Lunch, Meet Exhibitors and View Posters


Paul WattsKeynote Presentation

Drugs for Africa: Process Intensification for API Synthesis Exploiting Continuous Manufacturing
Paul Watts, Distinguished Professor and Research Chair, Nelson Mandela University, South Africa

While Africa has a variety of companies that formulate medicines, it does not have any form of pharmaceutical industry that manufactures the active pharmaceutical ingredients (APIs) with the consequence that these need to be imported. This results in increased drug costs making medications unaffordable to most patients in Africa. The current pandemic has further demonstrated supply chain issues when relying entirely on imported products.

To this effect, we are working on developing local drug manufacturing capacity in Africa using continuous flow technology, with the goal of lowering the cost of drugs, improving drug accessibility and ultimately improving Africa’s health. We are developing cost effective and efficient continuous flow synthetic processes towards a variety of drugs to demonstrate that they can be manufactured at lower cost in Africa. The presentation will give a few case studies.


Continuous-Flow Approach Towards Synthetic CBD
Rodrigo Souza, Associate Professor, Federal University of Rio de Janeiro, Brazil

Recently, CBD was included in some countries as an antiepileptic product for compassionate use in children with refractory epilepsy. With the growth in the demand of CBD, comes a need for high purity-grade cannabinoids for the emerging market. The discovery and development of approaches toward cannabidiol synthesis have emerged from the extraction of the cannabis plants to cannabinoid fermentation in brewer’s yeast successfully. Here in we present our approach towards synthetic CBD by means fo continuous-flow protocol.


Late-Afternoon Coffee and Tea Break


Accelerated Development of Quantum Dots by Autonomous Robotic Experimentation in Flow
Milad Abolhasani, Assistant Professor, North Carolina State University, United States of America

In this talk, I will present the Artificial Chemist technology, that is, a modular flow chemistry platform operated by a machine learning-guided decision-making algorithm for accelerated development of energy-relevant colloidal nanomaterials. I will discuss the unique advantages of reconfigurable flow reactors for autonomous multi-step synthesis, optimization, and continuous manufacturing of colloidal quantum dots (QDs) for direct utilization in next-generation photonic devices. The Artificial Chemist can rapidly and efficiently (i) explore and learn the synthesis and processing universe of colloidal QDs, (ii) identify the composition and relevant synthesis and processing route(s) of QDs to achieve specific optical or optoelectronic properties, and (iii) continuously manufacture the rapidly optimized QDs at a fraction of time/cost of currently utilized batch techniques. The developed autonomous robotic experimentation strategy can be readily adapted for accelerated development and end-to-end manufacturing of other solution-processed nanomaterials.


Paul BohnKeynote Presentation

Fluidically-Coupled Electrochemical Immunosensing of Interleukin-6 in as a Biomarker for Traumatic Brain Injury and Covid-Related Cytokine Storms
Paul Bohn, Arthur J. Schmitt Professor of Chemical and Biomolecular Engineering and Professor of Chemistry and Biochemistry, University of Notre Dame, United States of America

A highly sensitive, label-free immunosensing platform based on interdigitated electrode arrays (IDEAs) has been developed for the detection of IL-6, a critical cytokine biomarker for inflammation and trauma. The IL-6 IDEA sensor exhibits a LOD in PBS that is comparable to other label-free sensors and ELISA-based electrochemical immunosensors, and it achieves linear ranges at IL-6 concentrations across 4 orders of magnitude for all fluids. Thus, the IL-6 IDEA sensor is an excellent candidate for clinical application as a POC tool, given its simple assembly, ease of operation, straightforward analysis, and good sensitivity for IL-6 in physiological fluids. Furthermore, preliminary experiments on non-optimized structures show that operation in generator-collector redox cycling mode can produce significant amplification factors. The performance of the IL-6 IDEA sensor was also explored in both CSF and serum. The IDEA sensor is less sensitive to IL-6 in CSF and serum than in in PBS, which is expected due to the presence of interferents, such as cellular debris, proteins, lipids, etc. Although LODs in CSF and serum were higher, the IL-6 IDEA electrochemical immunosensor can reliably detect IL-6 across 4 orders of magnitude at clinically relevant concentrations in CSF and serum. CSF is the preferred physiological fluid for biomarker detection due to its exceptionally low concentration of non-target interferents relative to blood plasma or serum.


In-Line Analysis In Flow: The Gateway to Smart Synthesis and Machine Learning in Chemistry
Michael Organ, Professor and Director of the Centre for Catalysis Research and Innovation , University of Ottawa, Canada

In-process reaction monitoring with GCMS, LCMS, and NMR spectroscopy has been developed to accurately track reaction performance. This has facilitated the incorporation of feed-back loops between the reactor effluent stream and the front end of the reactor using in-house developed software for hands-free continuous reaction optimization and production monitoring. Of course, samples must first be extracted from continuous processes in order to perform the above mentioned in-line analysis. This is often times thwarted by the presence of solids in the flowing stream, which can both block lines and valves and make analyses inaccurate. We have developed technology for the reliable handling of samples that contain solids from flow streams, which will be discussed.


Networking Reception with Beer and Wine: Network with Colleagues, Engage with Exhibitors and View Posters


Close of Day 1 of the Summit

Friday, 1 October 2021


Morning Coffee, Pastries and Networking in the Exhibit Hall


Amanda EvansKeynote Presentation

Title to be Confirmed.
Amanda Evans, Scientist, Los Alamos National Laboratory, United States of America


Title to be Confirmed.
Aaron Beeler, Assistant Professor, Boston University, United States of America


Mid-Morning Coffee Break and Networking

Add to Calendar ▼2021-09-30 00:00:002021-10-01 00:00:00Europe/LondonFlow Chemistry Summit 2021Flow Chemistry Summit 2021 in Boston, USABoston,