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SELECTBIO Conferences Innovations in API Manufacture 2022


Continuous-Flow C-C Coupling via Single-Atom Catalysis

Gianvito Vilé, Tenure-Track Assistant Professor in Chemical Engineering, Politecnico di Milano

Flow synthesis and single-atom catalysis are currently attracting a wide attention for sustainable chemical and pharmaceutical synthesis. In this lecture, I will demonstrate the synergistic merger of metallic single-atom catalysis and flow chemistry for the cross-coupling synthesis of pharmaceutically-relevant intermediates. Specifically, the metal and redox catalytic cycles are combined within one single-atom material which can be easily recovered and re-used in a flow reactor for several times, preserving its activity between individual trials. Finally, with the help of DFT calculations, I will elucidate the active site of the single-atom material and propose a plausible reaction mechanism for the flow reaction.

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