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SELECTBIO Conferences Circulating Biomarkers and Extracellular Vesicles Europe 2023


Nanotechnologies for Isolating and Characterizing Extracellular Nanocarriers of Biomarkers

Hsueh-Chia Chang, Bayer Professor of Engineering / Director, University of Notre Dame

We review a suite of nanotechnologies from our lab for high-throughput and scalable purification, enrichment and characterization of extracellular vesicles. The technologies are designed for medical diagnostics and biomarker discovery with physiological samples and for large-volume manufacturing of therapeutic exosomes. The relevant nanocarriers are exosomes, lipoproteins or protein-RNA complexes that carry potential protein and nucleic acid biomarkers for cancer, cardiovascular, neurodegenerative and even mental diseases.  The technologies include size-based ultrafiltration membranes with conic nanopores to reduce protein fouling, bipolar membranes that can split water and actuate on-chip pH gradient to allow rapid and continuous isoelectric separation of nanocarriers by charge, superparamagnetic traps of immuno-nanobeads for rapid affinity and activity assay of specific nanocarriers, electrokinetic nanoporous microsensors that can profile surface proteins of nanocarriers, solid-state nanopore sensor for profiling microRNA cargoes etc.

Add to Calendar ▼2023-06-19 00:00:002023-06-20 00:00:00Europe/LondonCirculating Biomarkers and Extracellular Vesicles Europe 2023Circulating Biomarkers and Extracellular Vesicles Europe 2023 in Rotterdam, The NetherlandsRotterdam, The