Abstract

Towards On-Demand Synthesis of Organic Small Molecules Through Advanced Flow Technology

Wu Jie, Assistant Professor, Chemistry Department, National University of Singapore

On-demand synthesis of complex molecules represents one of the ultimate goals for organic synthesis. In this talk, I will present some of our recent efforts towards this goal employing advanced flow reactors. A circulation flow has been utilized for solid-involved difunctionalization of ethylene. Continuous flow reactors were applied to achieve stepwise on-demand functionalization of multihydrosilanes using neutral eosin Y-based hydrogen atom transfer photocatalysis. An SPS-flow system was employed to enable automated API synthesis that can deliver analogues in an on demand and button-push fashion.