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SELECTBIO Conferences Lab-on-a-Chip and Microfluidics Europe 2023


Digital Manufacturing of Functional Microfluidic Systems: Autonomous Capillaric Circuit

David Juncker, Professor and Chair, McGill University

The culmination of digital manufacturing is the seamless manufacture of a functional device from a digital design. Additive manufacturing is now used for making microfluidic chips, but microfluidics digital manufacturing is lagging, notably because functional systems depend on proprietary peripherals and a computer, and rely on generic, mass manufactured chips. Here I will discuss capillaric circuits (CCs) which are capillary-driven microfluidics that structurally encode simple algorithms of flow events into the circuit microarchitecture, and illustrate how application-specific CCs can be 3D printed using common, widely available stereolithography 3D printers. By encoding so-called microfluidic chain reactions, CCs can be programmed to execute step-by-step hundreds of sequential fluidic operations powered by a paper only, without electricity of peripheral connections. CCs have notably been used for automating an ELISA-on-a-chip for COVID19 antibody and antigen assays, and for the first microfluidic thrombin generation assay. Thanks to a new hydrophilic resin formulation, it is now possible to download a CC design, 3D-print it – which we demonstrate using ultra low-cost (US$300) LCD printers – clean it and use it within 30 minutes. These advances open the door for distributed and digital manufacturing of functional microfluidic CCs and systems by anyone, anywhere, anytime.

Add to Calendar ▼2023-06-19 00:00:002023-06-20 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics Europe 2023Lab-on-a-Chip and Microfluidics Europe 2023 in Rotterdam, The NetherlandsRotterdam, The