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SELECTBIO Conferences Microphysiological Systems 2023: A Deep Dive into Technologies & Applications


Design and Operation of Pumpless Multi-Organ Microphysiological Devices

Mandy Esch, Project Leader, NIST

We have developed pumpless multi-organ cell culture systems that can be used to co-culture interconnected human tissues to probe inter-organ interactions and secondary drug toxicities. Short connections among organ-chambers and pumpless operation using gravity-driven flow enable us to reduce the amount of liquid typically needed to operate the microfluidic cell culture systems. The devices can be operated with near-physiological amounts of recirculating blood surrogate (cell culture medium). We demonstrate the systems with heart and liver tissues scaled at 1/75,000. Our approach allows us to reduce the dilution of recirculating drug metabolites that cause acute toxicity and long-term toxicity. Better predictions of drug toxicity and efficacy with in vitro systems are needed, since clinical trials with humans often do not reproduce the results seen with animal models.

Add to Calendar ▼2023-07-26 00:00:002023-07-27 00:00:00Europe/LondonMicrophysiological Systems 2023: A Deep Dive into Technologies and ApplicationsMicrophysiological Systems 2023: A Deep Dive into Technologies and Applications in Orlando, FloridaOrlando,