08:00 | Registration & Breakfast Networking |
09:15 | | Keynote Presentation Developing and Scaling Multistep Flow Chemistry Klavs Jensen, Professor, Massachusetts Institute Of Technology, United States of America
Examples of development of scaling of multistep flow chemistry are presented along with ultrafiltration strategies for recycling of homogeneous catalysts. |
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10:00 | Catalysis in Flow: Operando Study of Pd Catalyst Speciation and Leaching Mimi Hii, Professor, Imperial College London, United Kingdom
The behaviour of palladium catalysts during a Suzuki-Miyaura cross-coupling reaction was examined using X-ray absorption spectroscopy. |
10:30 | Coffee & Networking in Exhibition Hall |
11:15 | TiContinuous Flow Synthesis of Alpha-Haloketones – Essential Building Blocks of Antiretroviral Agents C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz, Austria
A continuous flow strategy for the preparation of the HIV protease inhibitor Atazanavir will be described that relies on the safe generation of anhydrous diazomethane by membrane separation technology. |
11:45 | TiSynthetic Transformations Employing Continuous Flow Technologies Charles Liotta, Regents Professor & Chair, Georgia Tech School of Chemical & Biomolecular Engineering, United States of America
The utilization of continuous flow technologies for the following applications will be discussed: Synthesis of (S)-1-benzyl-3-diazo-2-oxopropylcarbamic acid tert-butyl ester, Synthesis of N-(tert-butoxycarbonyl)-(3S)-3-3amino-1-chloro-4-phenyl-(2S)-butane-2-ol via Meerwein-Ponndorf-Verley reduction, and Studies related to the indium-catalyzed Homo-Nazarov cyclization. |
12:15 | Flow Chemistry: A Useful Method for Performing Hazardous Exothermic Chemistry in a Safer Manner Heather Graehl, Director of Sales North America, ThalesNano, United States of America
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12:45 | Technology Spotlight: Recent Advances in Flow Chemistry Technology Billy Bullock, Regional Manager, Syrris Inc
In the last 10 years flow chemistry has evolved from obscurity to the most rapidly developing synthetic chemistry process. Chemists are now able to perform a wider range of faster, cleaner, safer chemistry. This presentation specifically looks at how specific areas of flow chemistry have developed over the last 2-3 years, from both the chemistry and technology viewpoints. This presentation looks at a selection of these benefits through real examples done by users of Syrris flow systems and investigates some recent advances in flow chemistry technology. |
13:00 | Lunch & Networking in Exhibition Hall |
13:30 | Poster Viewing Session |
14:15 | |
15:00 | Process Analysis Utilizing Small Footprint Capillary Flow based NMR Spectroscopy John Frost, Chemist, Thermo Fisher Scientific, United States of America
We present several systems utilizing the picoSpin NMR spectrometer for reaction monitoring applications in the process environment using readily available instruments and off the shelf components. A detailed discussion of the experimental setup, results and potential applications in the area of process analysis will be discussed. |
15:30 | Coffee & Networking in Exhibition Hall |
16:00 | Development of a Process Analytical Solution for Real-Time Monitoring of Continuous Flow Reactors Brian Marquardt, Director, University of Washington, United States of America
Development and implementation of accurate sampling systems and advanced analytics will greatly speed the development of new chemistries, streamline reaction optimization and vastly improve production quality and control in continuous flow reactors. |
16:30 | Multiphysics Modeling in Modern Flow Chemistry Patrick Mills, Professor and Dotterweich Endowed Chair, Texas A&M University Kingsville, United States of America
An overview of various software tools for detailed modeling of flow chemistry systems is presented along with recent applications. The capabilities of COMSOL Multiphysics are illustrated through target applications involving transport of momentum, energy and species transport in microreactor systems. |
17:00 | Close of Day One |