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SELECTBIO Conferences 2D-to-3D Culture and Organoids 2020

Peter Ertl's Biography

Peter Ertl, Professor of Lab-on-a-Chip Systems, Vienna University of Technology

Prof. Ertl holds an engineering degree in Biotechnology (University of Life Sciences, BOKU, Austria), a PhD in Chemistry (University of Waterloo, UW, Canada) and received his postdoctoral training as a biophysicist at University of California at Berkeley (UCB, US). Following a position as Director of Product Development at a UW spin-off venture (Canada), Dr. Ertl joint the Biosensor Technology unit at the Austrian Institute of Technology (AIT). During his tenure at the AIT, Dr. Ertl was also granted a Fulbright Visiting Scholarship at UC Berkeley (2012) and conducted visiting scientist positions at Nanyang Technological University, Singapore (2013), the Medical Center of the University of California at San Francisco (2014). In 2016 he was appointed Professor of Lab-on-a-Chip Systems for Bioscience Technologies at the Vienna University of Technology (TUW), where his research focuses on the development of advanced in vitro diagnostic microsystems and organ-on-a-chip systems. Additionally, Dr Ertl held a visiting research appointment at Imperial College London (UK) in 2019 , is speaker of the Austrian Microfluidics Initiative (AMI) and editor of the open access journal Organs-on-a-Chip (Elsevier).

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Parkinson’s-On-a-Chip: Unravelling the Complexity of Neurodegenerative Diseases Using a Chip-based Midbrain Organoid Model

Wednesday, 19 August 2020 at 11:00

Add to Calendar ▼2020-08-19 11:00:002020-08-19 12:00:00Europe/LondonParkinson’s-On-a-Chip: Unravelling the Complexity of Neurodegenerative Diseases Using a Chip-based Midbrain Organoid Model2D-to-3D Culture and Organoids 2020 in Boston, USABoston,

One of the main limitations in neuroscience and in the modeling and understanding of neurodegenerative diseases is the lack of advanced experimental in vitro models that truly mimic the complexity of the human brain. With its ability to emulate microarchitectures and functional characteristics of native organs in vitro, induced pluripotent stem cell technology has enabled the generation of human midbrain organoids. To improve organoid reproducibility and iPSC differentiation, we have developed a sensor-integrated organ-on-a-chip platform allowing long-term cultivation and non-invasive monitoring of hMOs under an interstitial flow regime. Our results show that dynamic cultivation of iPSC-derived hMOs maintains high cellular viabilities and dopaminergic neuron differentiation over prolonged cultivation periods of up to 50 days, while neurotransmitter release of hMOs is detected using an electrochemical sensor array.

Add to Calendar ▼2020-08-19 00:00:002020-08-20 00:00:00Europe/London2D-to-3D Culture and Organoids 20202D-to-3D Culture and Organoids 2020 in Boston, USABoston,