Nan Zhang,
Assistant Professor,
University College Dublin
Dr Nan Zhang is an Assistant Professor in Manufacturing and Design at the School of Mechanical and Materials Engineering at University College Dublin (UCD) in Ireland. His research covers polymer micro/nano manufacturing, precision manufacturing of plastic microfluidic chips, microfluidic systems for synthesizing genetic nanomedicine and molecular diagnostics, manufacturing functional micro/nano structured surfaces, and atomic and close-to-atomic-scale manufacturing. Dr Zhang won 4.5Million grant in his early career, including an H2020 MSCA ITN Grant as a consortium coordinator. Science Foundation Ireland, Enterprise Ireland-Commercialization Funding, Irish Research Council etc., funded his work. He has published more than 60 peer-reviewed journal papers in Materials Today, Nano Letters and the International Journal of Machine Tool and Manufacture. He was the chair of the 6th and 8th international conferences on polymer replication on the nanoscale (PRN2019, PRN2022). He is the associate editor of the journal “Frontier-Lab on Chip Technology” and a Council member of the Microfluidic Association. Dr Zhang also works as an international Committee Member for the standards organizations ISO/TC 48/WG3-Microfluidic Devices and ISO/TS WD 6417 (E) Microfluidic Pumps Symbols and Performance Communication. His research has generated several patents which have been commercialized or are in the process of being commercialized.
Screening and Scale-Up Lipid Nanoparticles Using a High-Throughput Microfluidic System
Tuesday, 14 November 2023 at 10:00
Add to Calendar ▼2023-11-14 10:00:002023-11-14 11:00:00Europe/LondonScreening and Scale-Up Lipid Nanoparticles Using a High-Throughput Microfluidic SystemExtracellular Vesicles and Nanoparticle-based Therapeutics Europe 2023 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Drug delivery systems in forms of nanoparticles have a broad spectrum of applications in area of gene therapy, cell therapy, and vaccine development. Lipid nanoparticles (LNPs) or liposomes that consist of a lipid bilayer and have a hollow structure are the most widely used drug carriers for nanomedicines. It is possible to encapsulate a variety of low molecular compounds (e.g., drugs, peptides, antibody, plasmid-DNA, mRNA, siRNA etc.) in the lipid bilayer membrane or to encapsulate them into the hollow structure. However, significant concerns remain on efficacy, safety, consistency, scale-up of manufacturing and stability when translating LNPs from formulation into clinical application. LNPs’ properties, e.g., size, size distribution, charge, drug encapsulation, transfection efficiency etc., can significantly affect the bio-distribution and pharmacokinetics of the drug to be delivered. In order to obtain LNPs with expected characteristics, microfluidics that exploit fluidic control to synthesize LNPs have grown in acceptability and applications in laboratory and larger scales due to offering a reproducible and robust manufacturing through the precise control of flowing conditions. In the present talk, the author will share the newly developed high throughput microfluidic system for laboratory screening and formulation of nanoparticles based on a novel aerofoil microfluidic mixing system. The formulation based on low, medium and high flow rates will be demonstrated. The automation of the system will be introduced for industrial scale formulation. The device has demonstrate the strong potential for low volume screening, medium volume scale up and high volume GMP production for nanoparticle development.
Add to Calendar ▼2023-11-13 00:00:002023-11-14 00:00:00Europe/LondonExtracellular Vesicles and Nanoparticle-based Therapeutics Europe 2023Extracellular Vesicles and Nanoparticle-based Therapeutics Europe 2023 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2023-11-14 10:00:002023-11-14 11:00:00Europe/LondonScreening and Scale-Up Lipid Nanoparticles Using a High-Throughput Microfluidic SystemExtracellular Vesicles and Nanoparticle-based Therapeutics Europe 2023 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
