Shopping Cart (0)
My Account

Shopping Cart
SELECTBIO Conferences Flow Chemistry Congress 2018

François Lévesque's Biography

François Lévesque, Associate Principal Scientist Process Chemistry, Merck & Co.

François is an associate principal scientist leading the flow chemistry team within the enabling technologies group at Merck & Co., Inc. The flow team works closely with the larger chemistry organization to explore the synthesis of challenging bioactive substrates for late stage discovery and to implement flow chemistry processes in late stage and commercial route development. Prior to joining Merck François worked at UCB in Belgium where he took part in the implementation of continuous flow chemistry tools for medicinal chemists.

François started to explore the full potential of flow chemistry during his post-doctoral fellowship at Max-Planck Institute for Colloids and Interfaces under the guidance of Pr. Peter H. Seeberger. While in Germany, François worked on the generation of singlet oxygen and the synthesis of Artemisinin in flow. He also explored high temperature reactions, photochemical transformation and the direct coupling of a flow reactor with simulated moving-bed chromatography (SMB). He holds a PhD, MSc and BSc in Chemistry from the Université de Sherbrooke in Canada. His PhD thesis focused on the synthesis of complex polycyclic alkaloids from simple linear precursors.

François Lévesque Image

Photochemistry as an Enabling and Scalable Tool

Monday, 12 November 2018 at 13:00

Add to Calendar ▼2018-11-12 13:00:002018-11-12 14:00:00Europe/LondonPhotochemistry as an Enabling and Scalable ToolFlow Chemistry Congress 2018 in Miami, FloridaMiami,

The past ten years have seen the exponential growth of reactions promoted by visible and UV light. This has led to the discovery of very useful and highly selective transformations that were not feasible without the use of photons. Due to the unique advantages of these reactions, we foresee an increasing use of photochemistry chemistry in the synthesis and production of API. Scaling-up these reactions remains a key challenge. As most photochemical reactions require a high surface area to volume ratio for good efficiency, the utilization of these transformations on large scale is most amenable to flow.  Our discussion will highlight the key parameters that need to be taken into account for an effective transition from the lab scale to preparative scale, namely geometry of the reactor, light source, photon density, path length, and residence time. Ongoing efforts by the flow chemistry team at Merck & Co., Inc. toward developing scalable photochemical reactions in flow and their application in specific case studies will be presented.

Add to Calendar ▼2018-11-12 00:00:002018-11-13 00:00:00Europe/LondonFlow Chemistry Congress 2018Flow Chemistry Congress 2018 in Miami, FloridaMiami,