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SELECTBIO Conferences Innovations in Microfluidics 2023

Tran Ngoc Huyen Nguyen's Biography

Tran Ngoc Huyen Nguyen, Postdoctoral Scholar, University of Washington

Tran N. H. Nguyen received her B.S. in Chemical Biology from the University of California, Berkeley. After completing a Ph.D. in Biomedical Engineering from Purdue University, she moved to Seattle for a postdoc in the Bioengineering Department at the University of Washington. Her research goals focus on developing high-performing point-of-care/implantable biosensors and microfluidic devices that can be applied to cancer and other chronic diseases.

Tran Ngoc Huyen Nguyen Image

Detection of Cytochrome C from Micro-Dissected Tumors in Microfluidic Arrays using Aptamer-Based Electrochemical Sensors

Friday, 5 May 2023 at 17:00

Add to Calendar ▼2023-05-05 17:00:002023-05-05 18:00:00Europe/LondonDetection of Cytochrome C from Micro-Dissected Tumors in Microfluidic Arrays using Aptamer-Based Electrochemical SensorsInnovations in Microfluidics 2023 in

Functional assays on intact tissues can potentially complement and extend genomics-based approaches for precision oncology by capturing key determinants of therapeutic response, such as tissue architecture, tumor heterogeneity, and the tumor microenvironment (TME). The Folch lab has recently developed a platform for drug development and cancer precision therapy based on a multi-well microfluidic device that can selectively treat a large array of regularly sized, cuboidal-shaped microdissected tissues (referred to as “cuboids”). The tissues are never dissociated and retain much of the native TME. However, the present platform only provides fluorescent readouts, which is a semi-quantitative method best suited to be a single-time-point terminal assay or labor-intensive terminal immunostaining analysis. Thus, we seek to develop a novel platform based on aptamer-based electrochemical sensing, which enables the periodic monitoring of cytochrome c, a cell death indicator. Using the platform, we demonstrate the ability to measure cytochrome c from live cuboids cultured with different drug conditions on our platform.

Add to Calendar ▼2023-05-04 00:00:002023-05-05 00:00:00Europe/LondonInnovations in Microfluidics 2023Innovations in Microfluidics 2023 in