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SELECTBIO Conferences Bioengineering for Building Microphysiological Systems 2022

Olivier Frey's Biography

Olivier Frey, Vice President Technologies and Platforms, InSphero AG

Olivier Frey is Vice President and Head of Technology & Platforms at InSphero and leads the Microphysiological Systems and Organ-on-Chip programs. Before joining InSphero, he was group leader and SNF Ambizione fellow at the Department of Biosystems Science and Engineering of ETH Zurich, Switzerland. He received his Doctoral degree in Micro Engineering from EPF Lausanne, Switzerland, at Laboratory of Prof. Nico de Rooij, and a Diploma in Microtechnology, Mechanics and Economics from ETH Zürich.

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Emulating Organ-Organ Interaction Using Scalable Microfluidics and Multi-Cellular Spheroids

Tuesday, 25 October 2022 at 12:00

Add to Calendar ▼2022-10-25 12:00:002022-10-25 13:00:00Europe/LondonEmulating Organ-Organ Interaction Using Scalable Microfluidics and Multi-Cellular SpheroidsBioengineering for Building Microphysiological Systems 2022 in Rotterdam, The NetherlandsRotterdam, The

Over the past years, we have developed the different technical and biological components ultimately merging into a scalable microfluidic multi-organ platform applicable for a broad spectrum of pre-clinical studies. An example we are currently advancing is a microphysiological 3D human liver – islet microtissue platform, that enables direct liver – pancreas crosstalk and a better understanding of metabolic diseases. We use 3D spheroids as biological organ models. They have become one of the most frequently used 3D cell culture systems in research and pharmaceutical industry, mainly due to their reasonable balance between physiological relevance and experimental complexity. The liver model consists of a primary Hepatocyte – Kupffer – Stellate cell triple-culture with preserved metabolic and inflammatory function over at least four weeks. Islet microtissues comprise all endocrine cells at physiological ratio and remain glucose responsive over the same duration. Both models are combined in microfluidic culturing device enabling interconnecting of up to ten 3D spherical microtissues. The microfluidic platform meets the requirements for scalability through the use of an injection-molding mass-fabrication process and a gravity-driven tubeless flow concept, which enables parallelization. Large-scale multi-tissue experiments are enabled with a fast and reliable method for loading of quality-controlled spheroids using a fully automated robotic pick-and place-transfer.

Add to Calendar ▼2022-10-24 00:00:002022-10-25 00:00:00Europe/LondonBioengineering for Building Microphysiological Systems 2022Bioengineering for Building Microphysiological Systems 2022 in Rotterdam, The NetherlandsRotterdam, The