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SELECTBIO Conferences Microphysiological Systems 2023: A Deep Dive into Technologies & Applications

Mandy Esch's Biography



Mandy Esch, Project Leader, National Institute of Standards and Technology (NIST)

Mandy B. Esch is a project leader in the Microsystems and Nanotechnology Division of the National Institute of Standards and Technology. She received a Diploma (equivalent to the American M.S. degree) in Biology and a Dr. rer. nat. (equivalent to the American Ph.D. degree) in Biotechnology from the Julius Maximilians University in W├╝rzburg, Germany. During her PhD research she developed paper-based microfluidics and microfluidic biosensors for the detection of pathogens. In 2001, Dr. Esch joined the Cornell Nanoscale Science and Technology Facility as life sciences liaison. In 2007, she joined the Department of Biomedical Engineering at Cornell University as a Postdoctoral Research Associate. While there, she developed patents for cell culture on a porous 3D surface and for a multi-organ microphysiological system (MPS). She was part of the team that in 2015 received the Lush Science Prize for designing multi-organ fluidic cell culture systems. From 2015 to 2016 Dr. Esch spent a year as Assistant Professor at Syracuse University (Department of Biomedical and Chemical Engineering), where she taught nanobiotechnology. In August 2016 Dr. Esch moved to NIST, where she is focusing on integrating sensors with tissues-on-chips and multi-organ microphysiological systems.

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Design and Operation of Pumpless Multi-Organ Microphysiological Devices

Wednesday, 26 July 2023 at 11:45

Add to Calendar ▼2023-07-26 11:45:002023-07-26 12:45:00Europe/LondonDesign and Operation of Pumpless Multi-Organ Microphysiological DevicesMicrophysiological Systems 2023: A Deep Dive into Technologies and Applications in Orlando, FloridaOrlando, FloridaSELECTBIOenquiries@selectbiosciences.com

We have developed pumpless multi-organ cell culture systems that can be used to co-culture interconnected human tissues to probe inter-organ interactions and secondary drug toxicities. Short connections among organ-chambers and pumpless operation using gravity-driven flow enable us to reduce the amount of liquid typically needed to operate the microfluidic cell culture systems. The devices can be operated with near-physiological amounts of recirculating blood surrogate (cell culture medium). We demonstrate the systems with heart and liver tissues scaled at 1/75,000. Our approach allows us to reduce the dilution of recirculating drug metabolites that cause acute toxicity and long-term toxicity. Better predictions of drug toxicity and efficacy with in vitro systems are needed, since clinical trials with humans often do not reproduce the results seen with animal models.


Add to Calendar ▼2023-07-26 00:00:002023-07-27 00:00:00Europe/LondonMicrophysiological Systems 2023: A Deep Dive into Technologies and ApplicationsMicrophysiological Systems 2023: A Deep Dive into Technologies and Applications in Orlando, FloridaOrlando, FloridaSELECTBIOenquiries@selectbiosciences.com