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SELECTBIO Conferences Next Generation Sequencing: Research to Clinic

Doron Lipson's Biography

Doron Lipson, Director, Foundation Medicine

Doron Lipson, Ph.D., has over 10 years of experience in developing genomic applications. He is currently leading a team responsible for developing clinical-grade computational methods for detecting driver alterations in tumors from NGS data at Foundation Medicine. Previously, has worked at Helicos BioSciences and at Agilent, and was a co-founder of ProteOptics, which was acquired by Bio-Rad in 2006. Doron received his Ph.D. and M.S. in Computer Science from Israel Institute of Technology, and his B.S. in Computer Science and Biology from the Hebrew University of Jerusalem. During his career Doron has been widely published in a variety of journals including Nature, Science, Nature Medicine, PNAS and Genome Research and has over 15 accepted and pending patents in the fields of microarrays, sequencing, and surface plasmon resonance.

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Analytical Challenges in Clinical Cancer Diagnostics by NGS

Monday, 24 February 2014 at 13:30

Add to Calendar ▼2014-02-24 13:30:002014-02-24 14:30:00Europe/LondonAnalytical Challenges in Clinical Cancer Diagnostics by NGSNext Generation Sequencing: Research to Clinic in San Diego, California, USASan Diego, California,

As the number of therapeutically-relevant cancer genes grows and biopsy size decreases, next-generation sequencing becomes increasingly attractive as a diagnostic tool for informing rationally targeted therapies. Developing an NGS-based test for use in clinical decision making poses significant analytical challenges, including the requirement to detect all classes of genomic alterations and to validate the accuracy of the assay across a wide range of possible alterations; limited amount and heterogeneity of tumor specimens; common unavailability of patient-matched normal control samples; and the need to provide molecular information in a format that can be readily interpreted by clinicians. I will discuss our approach in developing a comprehensive, pan-cancer diagnostic assay and experience analyzing over 9,000 clinical specimens in our CLIA-certified laboratory, which has demonstrated potentially actionable alterations in 80% of cases, and has led to numerous novel insights into cancer development.

Add to Calendar ▼2014-02-24 00:00:002014-02-25 00:00:00Europe/LondonNext Generation Sequencing: Research to ClinicNext Generation Sequencing: Research to Clinic in San Diego, California, USASan Diego, California,