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SELECTBIO Conferences Organoids & Organs-on-Chips 2021

Noah Malmstadt's Biography

Noah Malmstadt, Professor, Mork Family Dept. of Chemical Engineering & Materials Science, University of Southern California

Noah Malmstadt is Professor at the University of Southern California. He received a BS in Chemical Engineering from Caltech and a PhD in Bioengineering from the University of Washington. Following postdoctoral work at UCLA, he joined the Mork Family Department of Chemical Engineering and Materials Science at USC in 2007. Malmstadt is the recipient of a 2012 Office of Naval Research Young Investigator award. His research focuses on microfluidic strategies to facilitate material fabrication and biophysical analysis. He has pioneered the integration of ionic liquids as solvents in droplet microreactors and the application of microfluidic systems to synthesizing biomimetic cell membranes. Microfluidic analytical techniques he has developed include methods for measuring the permeability of cell membranes to druglike molecules and techniques for measuring ionic currents through membrane proteins.

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Biochemical Compatibility of Stereolithographic Resins

Wednesday, 15 December 2021 at 16:00

Add to Calendar ▼2021-12-15 16:00:002021-12-15 17:00:00Europe/LondonBiochemical Compatibility of Stereolithographic ResinsOrganoids and Organs-on-Chips 2021 in Coronado Island, CaliforniaCoronado Island,

While 3D printing offers a promising route to rapidly prototyping and manufacturing microfluidic systems, it relies on materials that have yet to be fully tested in a biological context. Stereolithographic 3D printing, for instance, requires polymer precursors that can be cured via free radical chain reaction polymerization, as well as associated initiators and dyes. We have examined the ability of devices printed with a variety of common SLA resin formulations to support common reactions used in molecular biology laboratories, including PCR, translation, transcription, and reverse transcription. We found that all reactions are inhibited by all materials; some to the point where there are no products present at the limit of detection. This inhibition occurs not only when the material is incubated with the reaction, but if the reaction is performed in buffer that had previously been exposed to the material, suggesting that inhibitory molecules are leached from the cured resin and into buffer. In most cases, significant activity can be recovered by performing the reaction in the presence of BSA, which potentially acts to adsorb inhibitory molecules.

Add to Calendar ▼2021-12-13 00:00:002021-12-15 00:00:00Europe/LondonOrganoids and Organs-on-Chips 2021Organoids and Organs-on-Chips 2021 in Coronado Island, CaliforniaCoronado Island,