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SELECTBIO Conferences Organoids and Organs-on-Chips Europe 2022

Elisabeth Verpoorte's Biography

Elisabeth Verpoorte, Chair of Analytical Chemistry and Pharmaceutical Analysis, University of Groningen

E.M.J. (Sabeth) Verpoorte has more than 30 years of research experience in the microfluidics or lab-on-a-chip field. Her introduction to this technology came in 1990, after her PhD with D. Jed Harrison at the University of Alberta, when she started as a postdoctoral researcher to the pioneering µTAS group headed by Professor Andreas Manz at Ciba Ltd., Basel, Switzerland. In 2003, Sabeth made a strategic switch to assume a Chair in the Groningen Research Institute of Pharmacy, making a foray into a new research environment dominated by cells, tissue and drug development. Ongoing projects involve the development of organ-on-a-chip systems to study drug metabolism (liver chip, gut chip), diagnose endothelial dysfunction and monitor liver tissue function. Efforts have also concentrated on continuous-flow particle separation strategies, paper microfluidics, as well as miniaturized analytical instrumentation (paper spray ionization, multidimensional chromatography). The acquisition of interdisciplinary projects involving scientists from the life sciences, chemistry, and physics disciplines continues to be a driving force in her research.

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Microfluidics as an Enabling Technology For Monitoring Liver Tissue Behaviour

Tuesday, 21 June 2022 at 15:00

Add to Calendar ▼2022-06-21 15:00:002022-06-21 16:00:00Europe/LondonMicrofluidics as an Enabling Technology For Monitoring Liver Tissue BehaviourOrganoids and Organs-on-Chips Europe 2022 in Rotterdam, The NetherlandsRotterdam, The

Microfluidics is in many ways a mature technology when it comes to culturing cells and tissue for physiological studies of healthy and diseased organ models in vitro. The idea that a researcher can manipulate the cellular microenvironment more effectively in small microchannels than larger containers has been well established in the organ-on-a-chip concept. The fluid handling control that is inherent to microfluidics has also been exploited to develop dynamic experiments in which conditions are changed precisely over time. Moreover, flow can be managed in such a way that medium can be continuously delivered to built-in sensors and/or external analysis systems, enabling quantitative monitoring of physiological processes. In this presentation, I will talk about some recent work we have done together with various partners in which we exploit microfluidics to achieve new analytical approaches to more comprehensively understand the behavior of precision-cut liver slices in vitro.

Add to Calendar ▼2022-06-21 00:00:002022-06-22 00:00:00Europe/LondonOrganoids and Organs-on-Chips Europe 2022Organoids and Organs-on-Chips Europe 2022 in Rotterdam, The NetherlandsRotterdam, The