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SELECTBIO Conferences ADME and Predictive Toxicology

Ingo Meier's Biography



Ingo Meier, Field Application Specialist, Sigma Life Science

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Ingo Meier Image

Investigating Transporter Function with P-Glycoprotein, MRP2 and BCRP Gene Knockout Caco-2 Cell Models

Thursday, 11 April 2013 at 12:15

Add to Calendar ▼2013-04-11 12:15:002013-04-11 13:15:00Europe/LondonInvestigating Transporter Function with P-Glycoprotein, MRP2 and BCRP Gene Knockout Caco-2 Cell Models ADME and Predictive Toxicology in Barcelona, SpainBarcelona, SpainSELECTBIOenquiries@selectbiosciences.com

The pharmacokinetic, efficacy and safety profiles of new drug candidates may be significantly affected by interactions with membrane transporters. Although assays currently exist to assess potential interactions for many transporters, these are often limited by the lack of specificity of inhibitors/substrates for a given transporter. To address this need, researchers at Sigma Life Science developed single and double knockout cell lines for the three major intestinal efflux transporters (MDR1, BCRP and MRP2) in a subclone of Caco-2 cells (C2bbe1). This presentation will provide an overview of the technology used to produce these cell lines as well as provide the genetic and functional data used to validate them.


Add to Calendar ▼2013-04-11 00:00:002013-04-12 00:00:00Europe/LondonADME and Predictive ToxicologyADME and Predictive Toxicology in Barcelona, SpainBarcelona, SpainSELECTBIOenquiries@selectbiosciences.com