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SELECTBIO Conferences Extracellular Vesicles (EVs: Exosomes and Microvesicles): Research, Diagnostics and Therapeutics Applications

John Ludlow's Biography

John Ludlow, Executive Director, Regenerative Medicine, Zen-Bio, Inc.

John W. Ludlow, Ph.D, is the Executive Director of Regenerative Medicine at Zen Bio Inc. (Research Triangle Park, NC.) Prior to joining the company in 2012, John was Senior Director, Process Research and Assay Development, at Tengion Inc., a tissue engineering and regenerative medicine company (Winston-Salem, NC.) He held this position for 7 years. John also served as Senior Director, Cell Therapy Program, Vesta Therapeutics, Inc., (formerly Incara Pharmaceuticals; Research Triangle Park, NC.) for 5 years. He has developed and managed research and pre-clinical programs, initiated clinical trial sites, and directed development activities for cell therapy and tissue engineered products. He is an inventor on 4 issued patents pertaining to regenerative medicine products, and has published over 100 articles. Working closely with regulatory agencies, John has helped to ensure approval of the company’s products. John began his career as a faculty member at the University of Rochester Cancer Center (NY), where for 10 years he maintained an independently funded research laboratory training graduate students and post-doctoral fellows in the area of tumor suppressor gene expression, protein structure, and function.

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Extracellular Vesicles: Potential for Treating Skin and Soft Tissue Injuries

Thursday, 29 March 2018 at 13:00

Add to Calendar ▼2018-03-29 13:00:002018-03-29 14:00:00Europe/LondonExtracellular Vesicles: Potential for Treating Skin and Soft Tissue

Several recent studies support the hypothesis that EVs containing exosomes can mediate the pro-healing effects of stem cells in different wound healing models. This presentation will review our recent progress in studying skin wound healing and soft tissue repair following application of EVs containing exosomes. Our data supports the notion that these vesicles downregulate the expression of pro-inflammatory cytokines and stimulate collagen production in cultures of primary human keratinocytes. In vivo studies revealed a more rapid time to wound-closure following topical application. In a rat tendon injury model, significant healing activity was demonstrated by EVs containing exosomes compared to vehicle alone. This information will be then placed in the context of potential therapeutic applications.

Add to Calendar ▼2018-03-28 00:00:002018-03-29 00:00:00Europe/LondonExtracellular Vesicles (EVs: Exosomes and Microvesicles): Research, Diagnostics and Therapeutics