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SELECTBIO Conferences Circulating DNA, Circulating RNA, Circulating Tumor Cells, Circulating Proteins

Ashish Yeri's Biography

Ashish Yeri, Bioinformatician, The Translational Genomics Research Institute (TGEN)

My research over the last three years at TGen has spanned areas in population genetics and extracellular RNA (exRNA) biomarker discovery. Over the last two years, I have been involved in various exRNA biomarker discovery projects ranging from neurological disease to brain injuries, where I have spearheaded the informatics analyses. The analysis consists of analyzing next generation sequencing – both whole transcriptomic data and small RNA data along with their clinical phenotypes to aid the discovery of RNA biomarkers. These have resulted in peer-reviewed articles currently under review and I have also presented findings from the exRNA biomarker discovery projects at several conferences (Second North American Saliva Conference, ISEV, ASEMV).

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Extracellular RNA Profiles in Central Nervous System Disease

Tuesday, 22 March 2016 at 08:00

Add to Calendar ▼2016-03-22 08:00:002016-03-22 09:00:00Europe/LondonExtracellular RNA Profiles in Central Nervous System

The timely diagnosis of neurological disease would help in assessing the risk of developing serious complications permanent brain damage. We are currently investigating the use of extracellular RNA (exRNA) expression in biofluids (plasma, urine and saliva) to serve as biomarkers for a more robust diagnosis of brain injury. ExRNAs, released from all cells in the body are carried within vesicles or bound to RNA-binding proteins in biofluids. Their dynamic expression profile in response to cellular stresses can be coupled with next generation sequencing technologies, allowing for the detection of thousands of RNA at the same time. Here, I present the utility of exRNA biomarkers to diagnose risk for neurological damage such as traumatic brain injuries, subarachnoid hemorrhage, Alzheimer’s, etc. The talk will cover the technologies used in the sequencing of these RNA biomarkers and the analysis methodology for time dependent gene expression data.

Add to Calendar ▼2016-03-21 00:00:002016-03-22 00:00:00Europe/LondonCirculating DNA, Circulating RNA, Circulating Tumor Cells, Circulating