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SELECTBIO Conferences Lab-on-a-Chip and Microfluidics Asia 2023

Yanyi Huang's Biography

Yanyi Huang, Professor, Peking University

Professor Yanyi Huang is Professor of Analytical Chemistry at Peking University, and holds Principle Investigator positions in Biomedical Pioneering Innovation Center (BIOPIC), Peking-Tsinghua Center for Life Sciences at Peking University, and Institute for Cell Analysis at Shenzhen Bay Laboratory. He received his BS and ScD degrees from Peking University, and conducted his postdoc research at Caltech and Stanford University. He is Fellow of Royal Society of Chemistry. He is working on technology development for integrative biology researches, especially the new methods for genomic sequencing and large scale microfluidics.

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Rapid and Signal Crowdedness-Robust In-Situ Sequencing through Hybrid Block Coding

Friday, 6 October 2023 at 09:00

Add to Calendar ▼2023-10-06 09:00:002023-10-06 10:00:00Europe/LondonRapid and Signal Crowdedness-Robust In-Situ Sequencing through Hybrid Block CodingLab-on-a-Chip and Microfluidics Asia 2023 in Tokyo, JapanTokyo,

Spatial transcriptomics technology has revolutionized our understanding of cell types and tissue organization, opening new possibilities for researchers to explore transcript distributions at subcellular levels. However, existing methods have limitations in resolution, sensitivity, or speed. To overcome these challenges, we introduce SPRINTseq (Spatially Resolved and signal-diluted Next-generation Targeted sequencing), an innovative in situ sequencing strategy that combines hybrid block coding and molecular dilution strategies. Our method enables fast and sensitive high-resolution data acquisition, as demonstrated by recovering over 142 million transcripts from 453,843 cells from four mouse brain coronal slices in less than two days. Using this advanced technology, we uncover the cellular and subcellular molecular architecture of Alzheimer's disease, providing unprecedented insights into abnormal cellular behaviors and their subcellular mRNA distribution. This improved spatial transcriptomics technology holds great promise for exploring complex biological processes and disease mechanisms.

Add to Calendar ▼2023-10-05 00:00:002023-10-06 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics Asia 2023Lab-on-a-Chip and Microfluidics Asia 2023 in Tokyo, JapanTokyo,