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SELECTBIO Conferences Lab-on-a-Chip and Microfluidics: Companies, Technologies and Commercialization

Ian Papautsky's Biography

Ian Papautsky, Richard and Loan Hill Professor of Bioengineering, Co-Director, NSF Center for Advanced Design & Manufacturing of Integrated Microfluidics, University of Illinois at Chicago

Dr. Papautsky is Richard and Loan Hill Professor of Bioengineering, Co-Director, NSF Center for Advanced Design & Manufacturing of Integrated Microfluidics in the Department of Bioengineering at the University of Illinois at Chicago. He received the B.S. degree in biomedical engineering from Boston University in 1995 and the Ph.D. degree in bioengineering from the University of Utah in 1999. His current research focuses on use of microfluidics in cell separations and point-of-care sensor systems. He is a member of the DARPA Microfluidic Fundamental Focus (MF3) Center, and a founding member of The Ohio Center for Microfluidic Innovation (OCMI). He received BioOhio 30 in their 30 Award in 2007.

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Inertial Microfluidics for Blood Fractionation

Wednesday, 4 October 2017 at 14:30

Add to Calendar ▼2017-10-04 14:30:002017-10-04 15:30:00Europe/LondonInertial Microfluidics for Blood

Sorting of cells from complex cellular mixtures is a critical sample preparation step in many biomedical and clinical applications. In the past two decades, microfluidics has introduced a number of techniques for cell soring, including both active and passive approaches. The burgeoning field of inertial microfluidics brings cell focusing and sorting functionalities at throughput orders of magnitude higher than previously available.  However, most inertial microfluidic devices rely on cross-sectional flow-induced drag force to achieve single-position focusing, which inevitably complicates the device design and operation.  Further, to ensure precise sorting of blood, inertial microfluidic devices typically require >20× blood dilution to avoid interparticle interaction, which results in large volume of sample and long processing time.  In addition, they often require long microchannel with small cross-section, which may increase the chance of channel clogging.  To overcome these challenges, we recently introduced a novel integrated microfluidic platform with simple straightforward geometry for efficient blood sorting with high throughput.  The simple geometry permits us to parallel the integrated device to achieve a throughput of ~18 mL/h.  Quantitative measurements indicate a ~99.97% sorting efficiency for Red Blood Cells. The approach offers a number of benefits, including simplicity in fundamental principle and geometry, convenience in design, modification and integration.  We note that one can conveniently parallel more units to further enhance throughput without adding significant complexity to the system.  We envision this device could serve as a powerful tool for blood fractionation and other cellular preparations in biomedical and clinical applications.

Add to Calendar ▼2017-10-02 00:00:002017-10-04 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics: Companies, Technologies and