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SELECTBIO Conferences Organ-on-a-Chip and Body-on-a-Chip: In Vitro Systems Mimicking In Vivo Functions "Track A"

Megan L McCain's Biography

Megan L McCain, Assistant Professor of Biomedical Engineering and Stem Cell Biology and Regenerative Medicine, University of Southern California Keck School of Medicine

Megan L. McCain, PhD, is the Chonette Early Career Chair and Assistant Professor in the Department of Biomedical Engineering at USC Viterbi School of Engineering and Stem Cell Biology and Regenerative Medicine at Keck School of Medicine of USC. Her research group, the Laboratory for Living Systems Engineering, engineers microscale mimics of human tissues, known as “Organs on Chips”. They implement these platforms to characterize human disease progression and identify promising therapeutic strategies on a personalized basis, with a focus on cardiac and skeletal muscle diseases. They also work closely with pharmaceutical companies to translate their platforms for next-generation pre-clinical drug screening. Megan is a recipient of a Scientist Development Grant from the American Heart Association and an Innovation Award from the Eli and Edythe Broad Foundation. She has also been recognized as a Top Innovator Under 35 by MIT Technology Review and a Young Innovator in Cellular and Molecular Bioengineering by the Biomedical Engineering Society. She received her PhD and postdoctoral training in Engineering Sciences from Harvard University.

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Striated Muscle Disease Modeling on a Chip

Friday, 5 October 2018 at 14:30

Add to Calendar ▼2018-10-05 14:30:002018-10-05 15:30:00Europe/LondonStriated Muscle Disease Modeling on a

Cardiac and skeletal muscle research has traditionally been limited to model systems that lack throughput and/or relevance to native human tissues, such as animal models or simplified cell cultures with minimal functional outputs. The reliance on these platforms has limited our ability to establish human disease mechanisms, identify effective therapeutic targets, and efficiently screen drugs for functional efficacy. In this talk, I will describe our efforts in integrating tunable biomaterials, microfabrication techniques, and human cells (including stem cell derivatives) to engineer scalable models of human cardiac and skeletal muscle tissues with quantitative functional outputs. I will also describe how we are leveraging these platforms to model acquired and inherited forms of striated muscle diseases.

Add to Calendar ▼2018-10-04 00:00:002018-10-05 00:00:00Europe/LondonOrgan-on-a-Chip and Body-on-a-Chip: In Vitro Systems Mimicking In Vivo Functions "Track A"