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SELECTBIO Conferences Circulating Biomarkers World Congress 2017

Saumya Das's Biography

Saumya Das, Assistant Professor in Medicine, Beth Israel Deaconess Medical Center and Mass General Hospital

Saumya Das M.D., Ph.D. is an Assistant Professor of Medicine at Beth Israel Deaconess Medical Center and Harvard Medical School and part of the Cardiovascular Institute. He is the lead PI of an NIH Common Fund Grant for studying extracellular RNAs as biomarkers in cardiovascular diseases, and his laboratory focuses on discovery of novel extracellular RNA biomarkers, understanding their role as mediators of intercellular communication, and developing therapeutic strategies using animal models.

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Plasma RNA Signatures of Cardiac Remodeling in Heart Failure Play a Role in Disease Pathogenesis

Monday, 20 March 2017 at 14:30

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In the modern era of revascularization, acute mortality from coronary artery disease has decreased. However, adverse cardiac remodeling associated with ischemic heart disease combined with the explosion of cardiometabolic diseases has led to an epidemic of heart failure. There is a large unmet need to discover novel prognostic biomarkers and functional mediators of cardiac remodeling that may be exploited for novel therapies. Plasma extracellular microRNAs have been characterized as diagnostic biomarkers in cardiovascular diseases. Our work has identified plasma microRNA signatures of cardiac remodeling in patients with chronic heart failure and in patients post myocardial infarction. Bioinformatics and network analyses combined with experimental work has demonstrated that the microRNA components of these signatures are highly interconnected and regulate pathways of inflammation, cell growth and fibrosis. Finally, the use of next generation sequencing techniques to expand the repertoire the plasma RNA biomarkers has identified non-miRNA small RNAs, including snoRNAs, Y-RNAs and tRNA fragments as possible novel biomarkers of cardiovascular diseases.

Add to Calendar ▼2017-03-20 00:00:002017-03-21 00:00:00Europe/LondonCirculating Biomarkers World Congress 2017Circulating Biomarkers World Congress 2017 in Boston, USABoston,