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SELECTBIO Conferences High-Content and Phenotypic Screening Europe 2018

Tristan Vaughan's Biography

Tristan Vaughan, Vice President, R&D, Antibody Discovery and Protein Engineering, MedImmune Ltd

Tris’s is the Site Leader for a team of 120 scientists responsible for discovering and engineering around half of MedImmune’s biologics portfolio. With core technologies such as phage/ribosome display, in vivo platforms, biologics screening and structural biology, his team supports delivery across multiple disease areas of a variety of biologics modalities. Prior to his current appointment, Tris held key responsibilities at Cambridge Antibody Technology and was integral to the successful CAT-AstraZeneca strategic alliance and prior to that for CAT’s Milestone and Royalty based Alliances, including that with Human Genome Sciences that discovered Benylsta®. He also developed the platform technology to build the first human antibody libraries of 1010 members and is a key inventor of Humira®, the world’s bestselling medicine. Before joining CAT, he was a postdoctoral fellow at the University of Toronto and a graduate of the University of Leeds Genetics Department. Tristan has over 50 publications in peer-reviewed journals.

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Overcoming Antigen-Mediated Antibody Clearance

Friday, 25 May 2018 at 16:00

Add to Calendar ▼2018-05-25 16:00:002018-05-25 17:00:00Europe/LondonOvercoming Antigen-Mediated Antibody ClearanceHigh-Content and Phenotypic Screening Europe 2018 in Cambridge, UKCambridge,

An antigen can act as a “sink” for antibody clearance if the antibody binds to an antigen which is rapidly eliminated. High levels of antibody clearance can impede and often halt the development of a novel therapeutic due to an impossibly large dose that would be required to overcome the sink for the drug to bring any patient benefit.  Here, an antibody engineering solution to rapid clearance will be described and a case study presented.

Add to Calendar ▼2018-05-24 00:00:002018-05-25 00:00:00Europe/LondonHigh-Content and Phenotypic Screening Europe 2018High-Content and Phenotypic Screening Europe 2018 in Cambridge, UKCambridge,