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SELECTBIO Conferences Circulating Biomarkers: Cell-Free Nucleic Acids, Proteins and Rare Circulating Cells

Agnieszka Bronisz's Biography

Agnieszka Bronisz, Instructor in Neurosurgery, Brigham and Women's Hospital/Harvard Medical School

Dr. Agnieszka Bronisz earned her Master degree in biology from University of Warsaw, Warsaw, Poland in 1997 and her Ph.D. degree in molecular neuropathology from the Medical Research Centre of Polish Academy of Sciences, Warsaw, Poland in 2001. Subsequently, Dr. Bronisz conducted post-doctoral training in molecular cell biology at the Texas A&M University Health Science Center and in molecular genetics and tumor microenvironment at The Ohio State University Comprehensive Cancer Center. In 2012 she joined the Department of Neurosurgery as Instructor of Neurosurgery at Brigham and Women’s Hospital/Harvard Medical School where she established her research group to study the role of cellular and extracellular non-codingRNA in the heterogeneity of glioblastoma.

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Inter- and Intra-Tumoral microRNA Heterogeneity

Tuesday, 21 March 2017 at 18:00

Add to Calendar ▼2017-03-21 18:00:002017-03-21 19:00:00Europe/LondonInter- and Intra-Tumoral microRNA

Despite the importance of molecular subtype classification of glioblastoma multiforme (GBM), the extent of extracellular vesicle (EV)-driven molecular and phenotypic re-programming remains poorly understood. To reveal complex subpopulation dynamics within the heterogeneous intra-tumoral ecosystem, we characterized microRNA expression and secretion in phenotypically diverse subpopulations of patient-derived GBM stem-like cells (GSC). As EVs and microRNAs convey information that drives phenotype and re-arrange the molecular landscape in a cell type-specific manner, we argue that intra-tumoral exchange of microRNA augments the heterogeneity of GSC that is reflected in highly heterogeneous profiles of microRNA expression in GBM subtypes.

Add to Calendar ▼2017-03-20 00:00:002017-03-21 00:00:00Europe/LondonCirculating Biomarkers: Cell-Free Nucleic Acids, Proteins and Rare Circulating