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SELECTBIO Conferences Lab-on-a-Chip and Microfluidics Europe 2023

Steve Soper's Biography

Steve Soper, Foundation Distinguished Professor, Director, Center of BioModular Multi-scale System for Precision Medicine, The University of Kansas

Prof. Soper (since 2016) is a Foundation Distinguished Professor in Chemistry and Mechanical Engineering at the University of Kansas. At KUMC, Prof. Soper holds an adjunct appointment in the Cancer Biology Department and is a member of the KU Cancer Center. He also holds an appointment at Ulsan National Institute of Science and Technology in Ulsan, South Korea, where he is a World Class University Professor.

As a result of his efforts, Prof. Soper has secured extramural funding totaling >$125M, has published over 245 peer-reviewed manuscripts (h index = 70; >17,000 citations); 31 book chapters and 71 peer-reviewed conference proceeding papers, and is the author of 12 patents. He is also the founder of a startup company, BioFluidica, which is marketing devices for the isolation and enumeration of liquid biopsy markers. Soper recently founded a second company, Sunflower Genomics, which is seeking to market a new DNA/RNA single-molecule sequencing platform. His list of awards includes Ralph Adams Award in Bioanalytical Chemistry, Chemical Instrumentation by the American Chemical Society, the Benedetti-Pichler Award for Microchemistry, Fellow of the AAAS, Fellow of Applied Spectroscopy, Fellow of the Royal Society of Chemistry, R&D 100 Award, Distinguished Masters Award at LSU and Outstanding Scientist/Engineer in the state of Louisiana in 2001. Finally, Prof. Soper has granted 50 PhDs and 7 MS degrees to students under his mentorship. He currently heads a group of 15 researchers.

His major discoveries include: (1) Technology for the detection of liquid biopsy markers that can manage a variety of diseases using a simple blood test (test has been demonstrated in multiple myeloma, pediatric acute lymphoblastic leukemia, acute myeloid leukemia, pancreatic, breast, colorectal, prostate, and ovarian cancers); (2) new hardware and assay for the point-of-care diagnosis of acute ischemic stroke; (3) single-molecule DNA and RNA sequencing nanotechnology; and (4) currently working on a home-test for COVID-19 infections (handheld instrument and the associated assay.

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In-Plane Nanopore Sensors made in by Injection Molding for Detecting and Identifying Single Molecules via Resistive Pulse Sensing

Monday, 19 June 2023 at 11:45

Add to Calendar ▼2023-06-19 11:45:002023-06-19 12:45:00Europe/LondonIn-Plane Nanopore Sensors made in by Injection Molding for Detecting and Identifying Single Molecules via Resistive Pulse SensingLab-on-a-Chip and Microfluidics Europe 2023 in Rotterdam, The NetherlandsRotterdam, The

Nanofluidic devices offer promising and highly innovative approaches for analyzing single molecules and obtaining biophysical information that cannot be realized using microfluidics due to scaling issues. The ability to provide reliable, rapid, quantitative, and low-cost identification of single molecules will offer exciting new opportunities for a broad range of biomedical applications. We are developing dual in-plane nanopore sensors in plastics for the label-free detection and identification of single molecules. The hypothesis behind our nanopore sensor is, “individual molecules moving electrokinetically through a 2D nanotube will experience a time-of-flight (ToF) that are dependent upon their molecular identity.” In this presentation we will discuss the high rate manufacturing of a nanopore sensor with sub-5 nm in-plane nanopores using nano-injection molding from a cyclic olefin polymer (COP) plastic. The in-plane pores are situated at either end of a nanochannel (50 x 50 nm; 5 µm long) that generate current transient signals to detect and deduce the identity of the single molecule. The ToF is dependent on the apparent electrophoretic mobility of the molecule. The identity is determined from the ToF, the current transient amplitudes, and dwell times using multi-parameter Principle Component Analysis (PCA). We will show the ability to detect (detection efficiency ~100%) single ribonucleotide and deoxynucleotide monophosphates with identification accuracies exceeding 98%. Integrating the in-plane nanopore sensor with a solid-state nanoreactor results in a nanofluidic device that can be configured to provide molecular information from unamplified DNA/RNA targets with unprecedented capabilities. This will transform single-molecule processing to allow servicing a broad biomedical community for a wide range of applications, for example single-molecule sequencing.

Add to Calendar ▼2023-06-19 00:00:002023-06-20 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics Europe 2023Lab-on-a-Chip and Microfluidics Europe 2023 in Rotterdam, The NetherlandsRotterdam, The